Role of Triggering Receptor Expressed on Myeloid Cells-1 in Kidney Diseases: A Biomarker and Potential Therapeutic Target

Overview

Journal Chin Med J (Engl)

Specialty General Medicine

Date 2024 May 29

PMID 38809056

Authors

Yuxi Fan

Ye Xu

Zhi Huo

Hedong Zhang

Longkai Peng

Xin Jiang

Angus W Thomson

Helong Dai

Affiliations

Soon will be listed here.

Abstract

Triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily. As an amplifier of the inflammatory response, TREM-1 is mainly involved in the production of inflammatory mediators and the regulation of cell survival. TREM-1 has been studied in infectious diseases and more recently in non-infectious disorders. More and more studies have shown that TREM-1 plays an important pathogenic role in kidney diseases. There is evidence that TREM-1 can not only be used as a biomarker for diagnosis of disease but also as a potential therapeutic target to guide the development of novel therapeutic agents for kidney disease. This review summarized molecular biology of TREM-1 and its signaling pathways as well as immune response in the progress of acute kidney injury, renal fibrosis, diabetic nephropathy, immune nephropathy, and renal cell carcinoma.

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