Relationship Between LncRNA MALAT1 and Chemo-radiotherapy Resistance of Cancer Cells: Uncovered Truths

Overview

Journal Cell Biochem Biophys

Specialties Biochemistry
Biophysics
Cell Biology

Date 2024 May 28

PMID 38806965

Authors

Ahmed Hjazi

Saade Abdalkareem Jasim

Farag M A Altalbawy

Harpreet Kaur

Hamza Fadhel Hamzah

Irwanjot Kaur

Mahamedha Deorari

Abhinav Kumar

Ahmed Elawady

Mohammed N Fenjan

Affiliations

Soon will be listed here.

Abstract

The advancement of novel technologies, coupled with bioinformatics, has led to the discovery of additional genes, such as long noncoding RNAs (lncRNAs), that are associated with drug resistance. LncRNAs are composed of over 200 nucleotides and do not possess any protein coding function. These lncRNAs exhibit lower conservation across species, are typically expressed at low levels, and often display high specificity towards specific tissues and developmental stages. The LncRNA MALAT1 plays crucial regulatory roles in various aspects of genome function, encompassing gene transcription, splicing, and epigenetics. Additionally, it is involved in biological processes related to the cell cycle, cell differentiation, development, and pluripotency. Recently, MALAT1 has emerged as a novel mechanism contributing to drug resistance or sensitivity, attracting significant attention in the field of cancer research. This review aims to explore the mechanisms through which MALAT1 confers resistance to chemotherapy and radiotherapy in cancer cells.

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PMID: 40034935 PMC: 11872035. DOI: 10.30699/ijp.2024.2022061.3256.

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