Functions and Mechanisms of LncRNA MALAT1 in Cancer Chemotherapy Resistance

Overview

Journal Biomark Res

Publisher Biomed Central

Date 2023 Feb 24

PMID 36829256

Authors

Junhui Hou

Gong Zhang

Xia Wang

Yuan Wang

Kefeng Wang

Affiliations

Soon will be listed here.

Abstract

Chemotherapy is one of the most important treatments for cancer therapy. However, chemotherapy resistance is a big challenge in cancer treatment. Due to chemotherapy resistance, drugs become less effective or no longer effective at all. In recent years, long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been found to be associated with the development of chemotherapy resistance, suggesting that MALAT1 may be an important target to overcome chemotherapy resistance. In this review, we introduced the main mechanisms of chemotherapy resistance associated with MALAT1, which may provide new approaches for cancer treatment.

Citing Articles

Deciphering the mechanisms of long non-coding RNAs in ferroptosis: insights into its clinical significance in cancer progression and immunology.

Ou S, Nie X, Qiu X, Jin X, Wu G, Zhang R Cell Death Discov. 2025; 11(1):14.

PMID: 39827195 PMC: 11743196. DOI: 10.1038/s41420-025-02290-6.

Epigenetic Role of Long Non-coding RNAs in Multiple Myeloma.

Mehra N, Sundaram S, Shah P, Rao A Curr Oncol Rep. 2025; 27(1):37-44.

PMID: 39776330 DOI: 10.1007/s11912-024-01623-5.

Evaluating sex-specific responses to western diet across the lifespan: impact on cardiac function and transcriptomic signatures in C57BL/6J mice at 530 and 640/750 days of age.

Stepanyan A, Brojakowska A, Zakharyan R, Hakobyan S, Davitavyan S, Sirunyan T Cardiovasc Diabetol. 2024; 23(1):454.

PMID: 39732652 PMC: 11682651. DOI: 10.1186/s12933-024-02565-9.

Robust self-supervised learning strategy to tackle the inherent sparsity in single-cell RNA-seq data.

Park S, Lee H Brief Bioinform. 2024; 25(6).

PMID: 39550222 PMC: 11568879. DOI: 10.1093/bib/bbae586.

Biological functions and molecular mechanisms of LINC01116 in cancer.

Shi K, Wang X, Huang L, Guo Q, Yuan W, Lv Y Heliyon. 2024; 10(21):e38490.

PMID: 39512466 PMC: 11539247. DOI: 10.1016/j.heliyon.2024.e38490.

References

Montemayor-Garcia C, Hardin H, Guo Z, Larrain C, Buehler D, Asioli S . The role of epithelial mesenchymal transition markers in thyroid carcinoma progression. Endocr Pathol. 2013; 24(4):206-12. PMC: 3875396. DOI: 10.1007/s12022-013-9272-9. View

Zhang W, Liu Y, Fu Y, Han W, Xu H, Wen L . RETRACTED: Long non-coding RNA LINC00160 functions as a decoy of microRNA-132 to mediate autophagy and drug resistance in hepatocellular carcinoma via inhibition of PIK3R3. Cancer Lett. 2020; 478:22-33. DOI: 10.1016/j.canlet.2020.02.014. View

Xiao Y, Pan J, Geng Q, Wang G . LncRNA MALAT1 increases the stemness of gastric cancer cells via enhancing SOX2 mRNA stability. FEBS Open Bio. 2019; 9(7):1212-1222. PMC: 6609564. DOI: 10.1002/2211-5463.12649. View

Kim Y, Joo K, Jin J, Nam D . Cancer stem cells and their mechanism of chemo-radiation resistance. Int J Stem Cells. 2014; 2(2):109-14. PMC: 4021765. DOI: 10.15283/ijsc.2009.2.2.109. View

Colombo N, Lorusso D, Scollo P . Impact of Recurrence of Ovarian Cancer on Quality of Life and Outlook for the Future. Int J Gynecol Cancer. 2017; 27(6):1134-1140. PMC: 5499966. DOI: 10.1097/IGC.0000000000001023. View

Li Z, Dou P, Liu T, He S . Application of Long Noncoding RNAs in Osteosarcoma: Biomarkers and Therapeutic Targets. Cell Physiol Biochem. 2017; 42(4):1407-1419. DOI: 10.1159/000479205. View

An J, Lv W, Zhang Y . LncRNA NEAT1 contributes to paclitaxel resistance of ovarian cancer cells by regulating ZEB1 expression via miR-194. Onco Targets Ther. 2017; 10:5377-5390. PMC: 5691924. DOI: 10.2147/OTT.S147586. View

Bai L, Wang A, Zhang Y, Xu X, Zhang X . Knockdown of MALAT1 enhances chemosensitivity of ovarian cancer cells to cisplatin through inhibiting the Notch1 signaling pathway. Exp Cell Res. 2018; 366(2):161-171. DOI: 10.1016/j.yexcr.2018.03.014. View

Li B, Chen P, Qu J, Shi L, Zhuang W, Fu J . Activation of LTBP3 gene by a long noncoding RNA (lncRNA) MALAT1 transcript in mesenchymal stem cells from multiple myeloma. J Biol Chem. 2014; 289(42):29365-75. PMC: 4200285. DOI: 10.1074/jbc.M114.572693. View

10.

Domvri K, Petanidis S, Anestakis D, Porpodis K, Bai C, Zarogoulidis P . Exosomal lncRNA PCAT-1 promotes Kras-associated chemoresistance via immunosuppressive miR-182/miR-217 signaling and p27/CDK6 regulation. Oncotarget. 2020; 11(29):2847-2862. PMC: 7381096. DOI: 10.18632/oncotarget.27675. View

11.

Clemson C, Hutchinson J, Sara S, Ensminger A, Fox A, Chess A . An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles. Mol Cell. 2009; 33(6):717-26. PMC: 2696186. DOI: 10.1016/j.molcel.2009.01.026. View

12.

Ding Y, Wen Y, Chuang C, Lin C, Yang Y, Liu Y . Combined Impacts of Genetic Variants of Long Non-Coding RNA MALAT1 and the Environmental Carcinogen on the Susceptibility to and Progression of Oral Squamous Cell Carcinoma. Front Oncol. 2021; 11:684941. PMC: 8276129. DOI: 10.3389/fonc.2021.684941. View

13.

Kim S, Harford J, Moghe M, Rait A, Pirollo K, Chang E . Targeted nanocomplex carrying siRNA against MALAT1 sensitizes glioblastoma to temozolomide. Nucleic Acids Res. 2017; 46(3):1424-1440. PMC: 5815062. DOI: 10.1093/nar/gkx1221. View

14.

Pouyanrad S, Rahgozar S, Ghodousi E . Dysregulation of miR-335-3p, targeted by NEAT1 and MALAT1 long non-coding RNAs, is associated with poor prognosis in childhood acute lymphoblastic leukemia. Gene. 2019; 692:35-43. DOI: 10.1016/j.gene.2019.01.003. View

15.

Bernard D, Prasanth K, Tripathi V, Colasse S, Nakamura T, Xuan Z . A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression. EMBO J. 2010; 29(18):3082-93. PMC: 2944070. DOI: 10.1038/emboj.2010.199. View

16.

Ni W, Wang X, Sun Y, Gao X . Meta-analysis of the association between rs619586 A>G polymorphism and cancer risk. J Int Med Res. 2020; 48(7):300060520941969. PMC: 7388131. DOI: 10.1177/0300060520941969. View

17.

Hou Z, Xu X, Fu X, Zhou L, Liu S, Tan D . Long non-coding RNA MALAT1 promotes angiogenesis and immunosuppressive properties of HCC cells by sponging miR-140. Am J Physiol Cell Physiol. 2019; 318(3):C649-C663. DOI: 10.1152/ajpcell.00510.2018. View

18.

Ji Q, Zhang L, Liu X, Zhou L, Wang W, Han Z . Long non-coding RNA MALAT1 promotes tumour growth and metastasis in colorectal cancer through binding to SFPQ and releasing oncogene PTBP2 from SFPQ/PTBP2 complex. Br J Cancer. 2014; 111(4):736-48. PMC: 4134507. DOI: 10.1038/bjc.2014.383. View

19.

Wilusz J . Long noncoding RNAs: Re-writing dogmas of RNA processing and stability. Biochim Biophys Acta. 2015; 1859(1):128-38. PMC: 4676738. DOI: 10.1016/j.bbagrm.2015.06.003. View

20.

Levine B, Kroemer G . Autophagy in the pathogenesis of disease. Cell. 2008; 132(1):27-42. PMC: 2696814. DOI: 10.1016/j.cell.2007.12.018. View