Emerging Contributions of Pluripotent Stem Cells to Reproductive Technologies in Veterinary Medicine

Overview

Journal J Dev Biol

Specialty Biology

Date 2024 May 28

PMID 38804434

Authors

Raiane Cristina Fratini de Castro

Tiago William Buranello

Kaiana Recchia

Aline Fernanda de Souza

Naira Caroline Godoy Pieri

Fabiana Fernandes Bressan

Affiliations

Soon will be listed here.

Abstract

The generation of mature gametes and competent embryos in vitro from pluripotent stem cells has been successfully achieved in a few species, mainly in mice, with recent advances in humans and scarce preliminary reports in other domestic species. These biotechnologies are very attractive as they facilitate the understanding of developmental mechanisms and stages that are generally inaccessible during early embryogenesis, thus enabling advanced reproductive technologies and contributing to the generation of animals of high genetic merit in a short period. Studies on the production of in vitro embryos in pigs and cattle are currently used as study models for humans since they present more similar characteristics when compared to rodents in both the initial embryo development and adult life. This review discusses the most relevant biotechnologies used in veterinary medicine, focusing on the generation of germ-cell-like cells in vitro through the acquisition of totipotent status and the production of embryos in vitro from pluripotent stem cells, thus highlighting the main uses of pluripotent stem cells in livestock species and reproductive medicine.

Citing Articles

Advancements and challenges in stem cell transplantation for regenerative medicine.

Wei L, Yan W, Shah W, Zhang Z, Wang M, Liu B Heliyon. 2024; 10(16):e35836.

PMID: 39247380 PMC: 11379611. DOI: 10.1016/j.heliyon.2024.e35836.

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