Pre-Infection Nutritional Status, Oxidative Stress, and One-Year-Long COVID Persistence in Patients Undergoing Hemodialysis: A Prospective Cohort Study

Overview

Journal Clin Pract

Publisher MDPI

Specialty General Medicine

Date 2024 May 28

PMID 38804402

Authors

Natalia Stepanova

Lesya Korol

Tetyana Ostapenko

Valeriia Marchenko

Olga Belousova

Lyudmyla Snisar

Iryna Shifris

Mykola Kolesnyk

Affiliations

Soon will be listed here.

Abstract

Background: Nutritional status's role in long COVID is evident in the general population, yet unexplored in patients undergoing hemodialysis (HD), posing a research gap. We hypothesized that pre-infection undernutrition in HD patients might impact long COVID persistence by accelerating oxidative stress. The present study aimed to investigate the association between pre-infection nutritional status, oxidative stress, and one-year-long COVID persistence in HD patients.

Methods: This prospective observational cohort study enrolled 115 HD patients with confirmed COVID-19. Nutritional status was assessed using the Controlling Nutritional Status (CONUT) score twice: before infection and three months post-infection. Oxidative markers included malondialdehyde (MDAs), ceruloplasmin, transferrin, and sulfhydryl groups. The endpoint was one-year-long COVID persistence.

Results: Moderate pre-infection CONUT scores were associated with heightened severe undernutrition risk ( < 0.0001), elevated MDAs ( < 0.0001), and reduced ceruloplasmin levels ( = 0.0009) at three months post-COVID-19 compared to light CONUT scores. Pre-infection CONUT score independently predicted post-COVID oxidative damage [OR 2.3 (95% CI 1.2; 4.6), < 0.0001] and one-year-long COVID persistence [HR 4.6 (95% CI 1.4; 9.9), < 0.0001], even after adjusting for potential confounders.

Conclusion: Moderate pre-infection undernutrition heightens post-COVID oxidative stress and increases the risk of one-year-long COVID persistence in HD patients.

Citing Articles

Long COVID or Post-Acute Sequelae of COVID-19 (PASC) in Children and Adolescents.

Setiabudi D, Azhali B, Tirtosudiro M, Ramadhan M, Rinaldhi M, Nataprawira H Clin Med Res. 2024; 22(3):131-137.

PMID: 39438144 PMC: 11495663. DOI: 10.3121/cmr.2024.1858.

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