Shape Matters: Impact of Mesoporous Silica Nanoparticle Morphology on Anti-Tumor Efficacy

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2024 May 25

PMID 38794294

Authors

Weixiang Fang

Kailing Yu

Songhan Zhang

Lai Jiang

Hongyue Zheng

Qiaoling Huang

Fanzhu Li

Affiliations

Soon will be listed here.

Abstract

A nanoparticle's shape is a critical determinant of its biological interactions and therapeutic effectiveness. This study investigates the influence of shape on the performance of mesoporous silica nanoparticles (MSNs) in anticancer therapy. MSNs with spherical, rod-like, and hexagonal-plate-like shapes were synthesized, with particle sizes of around 240 nm, and their other surface properties were characterized. The drug loading capacities of the three shapes were controlled to be 47.46%, 49.41%, and 46.65%, respectively. The effects of shape on the release behaviors, cellular uptake mechanisms, and pharmacological behaviors of MSNs were systematically investigated. Through a series of in vitro studies using 4T1 cells and in vivo evaluations in 4T1 tumor-bearing mice, the release kinetics, cellular behaviors, pharmacological effects, circulation profiles, and therapeutic efficacy of MSNs were comprehensively assessed. Notably, hexagonal-plate-shaped MSNs loaded with PTX exhibited a prolonged circulation time ( = 13.59 ± 0.96 h), which was approximately 1.3 times that of spherical MSNs ( = 10.16 ± 0.38 h) and 1.5 times that of rod-shaped MSNs ( = 8.76 ± 1.37 h). This research underscores the significance of nanoparticles' shapes in dictating their biological interactions and therapeutic outcomes, providing valuable insights for the rational design of targeted drug delivery systems in cancer therapy.

References

Yu W, Liu R, Zhou Y, Gao H . Size-Tunable Strategies for a Tumor Targeted Drug Delivery System. ACS Cent Sci. 2020; 6(2):100-116. PMC: 7047275. DOI: 10.1021/acscentsci.9b01139. View

Chen X, Fan X, Zhang Y, Wei Y, Zheng H, Bao D . Cooperative coordination-mediated multi-component self-assembly of "all-in-one" nanospike theranostic nano-platform for MRI-guided synergistic therapy against breast cancer. Acta Pharm Sin B. 2022; 12(9):3710-3725. PMC: 9513557. DOI: 10.1016/j.apsb.2022.02.027. View

Wang L . Preparation and evaluation of an acidic environment-responsive liposome for paclitaxel tumor targeting. Asian J Pharm Sci. 2020; 12(5):470-477. PMC: 7032246. DOI: 10.1016/j.ajps.2017.05.008. View

Tang L, Yang X, Yin Q, Cai K, Wang H, Chaudhury I . Investigating the optimal size of anticancer nanomedicine. Proc Natl Acad Sci U S A. 2014; 111(43):15344-9. PMC: 4217425. DOI: 10.1073/pnas.1411499111. View

Khizar S, Alrushaid N, Khan F, Zine N, Jaffrezic-Renault N, Errachid A . Nanocarriers based novel and effective drug delivery system. Int J Pharm. 2023; 632:122570. DOI: 10.1016/j.ijpharm.2022.122570. View

Khalil A, Rauf A, Alhumaydhi F, Aljohani A, Javed M, Khan M . Recent Developments and Anticancer Therapeutics of Paclitaxel: An Update. Curr Pharm Des. 2022; 28(41):3363-3373. DOI: 10.2174/1381612829666221102155212. View

Chaiwaree S, Prapan A, Suwannasom N, Laporte T, Neumann T, Pruss A . Doxorubicin-Loaded Human Serum Albumin Submicron Particles: Preparation, Characterization and In Vitro Cellular Uptake. Pharmaceutics. 2020; 12(3). PMC: 7150780. DOI: 10.3390/pharmaceutics12030224. View

Zhou Q, Ching A, Leung W, Szeto C, Ho S, Chan P . Novel therapeutic potential in targeting microtubules by nanoparticle albumin-bound paclitaxel in hepatocellular carcinoma. Int J Oncol. 2011; 38(3):721-31. DOI: 10.3892/ijo.2011.902. View

McGoron A . Meta-Analysis of Efficacy of Chemotherapy Delivered by Mesoporous Silica Nanoparticles to Tumor-Bearing Mice. Crit Rev Biomed Eng. 2021; 48(6):327-418. DOI: 10.1615/CritRevBiomedEng.2020035804. View

10.

Arora S, Kumar A, Batra A . Effect of Adjuvant Paclitaxel and Carboplatin on Survival in Early Triple-Negative Breast Cancer. JAMA Oncol. 2021; 7(3):460-461. DOI: 10.1001/jamaoncol.2020.7157. View

11.

Li W, Sun L, Xia Y, Hao S, Cheng G, Wang Z . Preoccupation of Empty Carriers Decreases Endo-/Lysosome Escape and Reduces the Protein Delivery Efficiency of Mesoporous Silica Nanoparticles. ACS Appl Mater Interfaces. 2018; 10(6):5340-5347. DOI: 10.1021/acsami.7b18577. View

12.

Tripathi J, Vasu B, Beg O, Gorla R, Kameswaran P . Computational simulation of rheological blood flow containing hybrid nanoparticles in an inclined catheterized artery with stenotic, aneurysmal and slip effects. Comput Biol Med. 2021; 139:105009. DOI: 10.1016/j.compbiomed.2021.105009. View

13.

Champion J, Mitragotri S . Shape induced inhibition of phagocytosis of polymer particles. Pharm Res. 2008; 26(1):244-9. PMC: 2810499. DOI: 10.1007/s11095-008-9626-z. View

14.

Yang R, Chang L, Wu J, Tsai M, Wang H, Kuo Y . Persistent tissue kinetics and redistribution of nanoparticles, quantum dot 705, in mice: ICP-MS quantitative assessment. Environ Health Perspect. 2007; 115(9):1339-43. PMC: 1964885. DOI: 10.1289/ehp.10290. View

15.

Zhang J, Su X, Weng L, Tang K, Miao Y, Teng Z . Gadolinium-hybridized mesoporous organosilica nanoparticles with high magnetic resonance imaging performance for targeted drug delivery. J Colloid Interface Sci. 2022; 633:102-112. DOI: 10.1016/j.jcis.2022.11.085. View

16.

Xu J, Lee S, Seo H, Pang L, Jun Y, Zhang R . Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins. Small. 2018; 14(50):e1803601. PMC: 6361670. DOI: 10.1002/smll.201803601. View

17.

Pan Y, Zhou S, Li Y, Parshad B, Li W, Haag R . Novel dendritic polyglycerol-conjugated, mesoporous silica-based targeting nanocarriers for co-delivery of doxorubicin and tariquidar to overcome multidrug resistance in breast cancer stem cells. J Control Release. 2020; 330:1106-1117. DOI: 10.1016/j.jconrel.2020.11.015. View

18.

Janicke P, Lennicke C, Meister A, Seliger B, Wessjohann L, Kaluderovic G . Fluorescent spherical mesoporous silica nanoparticles loaded with emodin: Synthesis, cellular uptake and anticancer activity. Mater Sci Eng C Mater Biol Appl. 2020; 119:111619. DOI: 10.1016/j.msec.2020.111619. View

19.

Downes K, Zuppa A, Sharova A, Neely M . Optimizing Vancomycin Therapy in Critically Ill Children: A Population Pharmacokinetics Study to Inform Vancomycin Area under the Curve Estimation Using Novel Biomarkers. Pharmaceutics. 2023; 15(5). PMC: 10220925. DOI: 10.3390/pharmaceutics15051336. View

20.

Huang Yang C, Horwitz S, McDaid H . Utilization of Photoaffinity Labeling to Investigate Binding of Microtubule Stabilizing Agents to P-Glycoprotein and β-Tubulin. J Nat Prod. 2022; 85(3):720-728. PMC: 9484556. DOI: 10.1021/acs.jnatprod.2c00106. View