Cooperative Coordination-mediated Multi-component Self-assembly of "all-in-one" Nanospike Theranostic Nano-platform for MRI-guided Synergistic Therapy Against Breast Cancer

Overview

Journal Acta Pharm Sin B

Publisher Elsevier

Specialty Pharmacology

Date 2022 Sep 30

PMID 36176903

Authors

Xiaojie Chen

Xudong Fan

Yue Zhang

Yinghui Wei

Hangsheng Zheng

Dandan Bao

Hengwu Xu

Ji-Gang Piao

Fanzhu Li

Hongyue Zheng

Affiliations

Soon will be listed here.

Abstract

Carrier-free multi-component self-assembled nano-systems have attracted widespread attention owing to their easy preparation, high drug-loading efficiency, and excellent therapeutic efficacy. Herein, MnAs-ICG nanospike was generated by self-assembly of indocyanine green (ICG), manganese ions (Mn), and arsenate (AsO ) based on electrostatic and coordination interactions, effectively integrating the bimodal imaging ability of magnetic resonance imaging (MRI) and fluorescence (FL) imaging-guided synergistic therapy of photothermal/chemo/chemodynamic therapy within an "all-in-one" theranostic nano-platform. The as-prepared MnAs-ICG nanospike had a uniform size, well-defined nanospike morphology, and impressive loading capacities. The MnAs-ICG nanospike exhibited sensitive responsiveness to the acidic tumor microenvironment with morphological transformation and dimensional variability, enabling deep penetration into tumor tissue and on-demand release of functional therapeutic components. and results revealed that MnAs-ICG nanospike showed synergistic tumor-killing effect, prolonged blood circulation and increased tumor accumulation compared to their individual components, effectively resulting in synergistic therapy of photothermal/chemo/chemodynamic therapy with excellent anti-tumor effect. Taken together, this new strategy might hold great promise for rationally engineering multifunctional theranostic nano-platforms for breast cancer treatment.

Citing Articles

An encounter between metal ions and natural products: natural products-coordinated metal ions for the diagnosis and treatment of tumors.

Liu X, Liu S, Jin X, Liu H, Sun K, Wang X J Nanobiotechnology. 2024; 22(1):726.

PMID: 39574109 PMC: 11580416. DOI: 10.1186/s12951-024-02981-9.

Biomedical applications of stimuli-responsive nanomaterials.

Chen X, Wu D, Chen Z MedComm (2020). 2024; 5(8):e643.

PMID: 39036340 PMC: 11260173. DOI: 10.1002/mco2.643.

A Novel Multi-Effect Photosensitizer for Tumor Destruction via Multimodal Imaging Guided Synergistic Cancer Phototherapy.

Sun K, Wang B, Li M, Ge Y, An L, Zeng D Int J Nanomedicine. 2024; 19:6377-6397.

PMID: 38952677 PMC: 11215494. DOI: 10.2147/IJN.S461843.

Theranostic nanoparticles ZIF-8@ICG for pH/NIR-responsive drug-release and NIR-guided chemo-phototherapy against non-small-cell lung cancer.

Lu K, Pan X, Zheng J, Cheng D, Zheng L, Zhang X J Mater Sci Mater Med. 2024; 35(1):32.

PMID: 38896160 PMC: 11186913. DOI: 10.1007/s10856-024-06802-1.

Manganese-derived biomaterials for tumor diagnosis and therapy.

Huang P, Tang Q, Li M, Yang Q, Zhang Y, Lei L J Nanobiotechnology. 2024; 22(1):335.

PMID: 38879519 PMC: 11179396. DOI: 10.1186/s12951-024-02629-8.

References

Huang R, Lee T . Cellular uptake of trivalent arsenite and pentavalent arsenate in KB cells cultured in phosphate-free medium. Toxicol Appl Pharmacol. 1996; 136(2):243-9. DOI: 10.1006/taap.1996.0031. View

Subbarayan P, Ardalan B . In the war against solid tumors arsenic trioxide needs partners. J Gastrointest Cancer. 2014; 45(3):363-71. DOI: 10.1007/s12029-014-9617-8. View

Dilda P, Hogg P . Arsenical-based cancer drugs. Cancer Treat Rev. 2007; 33(6):542-64. DOI: 10.1016/j.ctrv.2007.05.001. View

Fu X, Li Y, Zhao J, Yu L, Luo R, Liang Q . Will Arsenic Trioxide Benefit Treatment of Solid Tumor by Nano- Encapsulation?. Mini Rev Med Chem. 2019; 20(3):239-251. DOI: 10.2174/1389557519666191018155426. View

Huang L, Zhao S, Fang F, Xu T, Lan M, Zhang J . Advances and perspectives in carrier-free nanodrugs for cancer chemo-monotherapy and combination therapy. Biomaterials. 2020; 268:120557. DOI: 10.1016/j.biomaterials.2020.120557. View

Ma C, Wu M, Ye W, Huang Z, Ma X, Wang W . Inhalable solid lipid nanoparticles for intracellular tuberculosis infection therapy: macrophage-targeting and pH-sensitive properties. Drug Deliv Transl Res. 2020; 11(3):1218-1235. DOI: 10.1007/s13346-020-00849-7. View

Tang H, Li C, Zhang Y, Zheng H, Cheng Y, Zhu J . Targeted Manganese doped silica nano GSH-cleaner for treatment of Liver Cancer by destroying the intracellular redox homeostasis. Theranostics. 2020; 10(21):9865-9887. PMC: 7449918. DOI: 10.7150/thno.46771. View

Chen P, Pan W, Luo P, Phung H, Liu Y, Chiang M . Pollen-Mimetic Metal-Organic Frameworks with Tunable Spike-Like Nanostructures That Promote Cell Interactions to Improve Antigen-Specific Humoral Immunity. ACS Nano. 2021; 15(4):7596-7607. DOI: 10.1021/acsnano.1c01129. View

Yang J, Dai J, Wang Q, Cheng Y, Guo J, Zhao Z . Tumor-Triggered Disassembly of a Multiple-Agent-Therapy Probe for Efficient Cellular Internalization. Angew Chem Int Ed Engl. 2020; 59(46):20405-20410. DOI: 10.1002/anie.202009196. View

10.

Mei H, Cai S, Huang D, Gao H, Cao J, He B . Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification. Bioact Mater. 2021; 8:220-240. PMC: 8424425. DOI: 10.1016/j.bioactmat.2021.06.035. View

11.

Tang Y, Lei T, Manchanda R, Nagesetti A, Fernandez-Fernandez A, Srinivasan S . Simultaneous delivery of chemotherapeutic and thermal-optical agents to cancer cells by a polymeric (PLGA) nanocarrier: an in vitro study. Pharm Res. 2010; 27(10):2242-53. DOI: 10.1007/s11095-010-0231-6. View

12.

Chen X, Zou J, Zhang K, Zhu J, Zhang Y, Zhu Z . Photothermal/matrix metalloproteinase-2 dual-responsive gelatin nanoparticles for breast cancer treatment. Acta Pharm Sin B. 2021; 11(1):271-282. PMC: 7838055. DOI: 10.1016/j.apsb.2020.08.009. View

13.

Luo X, Gong X, Su L, Lin H, Yang Z, Yan X . Activatable Mitochondria-Targeting Organoarsenic Prodrugs for Bioenergetic Cancer Therapy. Angew Chem Int Ed Engl. 2020; 60(3):1403-1410. DOI: 10.1002/anie.202012237. View

14.

Lin J, Li C, Guo Y, Zou J, Wu P, Liao Y . Carrier-free nanodrugs for in vivo NIR bioimaging and chemo-photothermal synergistic therapy. J Mater Chem B. 2019; 7(44):6914-6923. DOI: 10.1039/c9tb00687g. View

15.

Gorrini C, Harris I, Mak T . Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov. 2013; 12(12):931-47. DOI: 10.1038/nrd4002. View

16.

Wang W, Jin Y, Xu Z, Liu X, Bajwa S, Khan W . Stimuli-activatable nanomedicines for chemodynamic therapy of cancer. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020; 12(4):e1614. DOI: 10.1002/wnan.1614. View

17.

Tao J, Fei W, Tang H, Li C, Mu C, Zheng H . Angiopep-2-Conjugated "Core-Shell" Hybrid Nanovehicles for Targeted and pH-Triggered Delivery of Arsenic Trioxide into Glioma. Mol Pharm. 2019; 16(2):786-797. DOI: 10.1021/acs.molpharmaceut.8b01056. View

18.

Cioloboc D, Kurtz Jr D . Targeted cancer cell delivery of arsenate as a reductively activated prodrug. J Biol Inorg Chem. 2020; 25(3):441-449. DOI: 10.1007/s00775-020-01774-3. View

19.

Liu R, Jing L, Peng D, Li Y, Tian J, Dai Z . Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy. Theranostics. 2015; 5(10):1144-53. PMC: 4533097. DOI: 10.7150/thno.11754. View

20.

Day N, Wixson W, Wyatt Shields 4th C . Magnetic systems for cancer immunotherapy. Acta Pharm Sin B. 2021; 11(8):2172-2196. PMC: 8424374. DOI: 10.1016/j.apsb.2021.03.023. View