The Whole Genome Sequence of Polish Vaccine Strain BCG Moreau

Overview

Journal Microbiol Spectr

Specialty Microbiology

Date 2024 May 17

PMID 38757975

Authors

Katarzyna Krysztopa-Grzybowska

Jakub Lach

Maciej Polak

Dominik Strapagiel

Jaroslaw Dziadek

Marcin Olszewski

Aleksandra A Zasada

Aniela Darlinska

Anna Lutynska

Ewa Augustynowicz-Kopec

Affiliations

Soon will be listed here.

Abstract

Importance: The whole genome sequence obtained is the only genomic sequence of the strain that has been used for vaccine production in Poland since 1955. Sequencing of different BCG lots showed that the strain was stable over a period of 59 years. The comprehensive genomic analysis performed not only enriches knowledge about the microevolution and attenuation of the BCG vaccine substrains but also enables the utilization of identified markers as a reference point in the genetic control and identity tests of the stability of the vaccine strain in the future.

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