Genome Sequence of Mycobacterium Bovis BCG Moreau, the Brazilian Vaccine Strain Against Tuberculosis

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 2011 Sep 15

PMID 21914899

Citations 21

Authors

Leonardo H F Gomes

Thomas D Otto

Erico A Vasconcellos

Patricia M Ferrao

Renata M Maia

Aline S Moreira

Marcelo A Ferreira

Luiz R R Castello-Branco

Wim M Degrave

Leila Mendonca-Lima

Affiliations

Soon will be listed here.

Abstract

Mycobacterium bovis bacillus Calmette-Guérin (BCG) is the only vaccine available against tuberculosis, and the strains used worldwide represent a family of daughter strains with distinct genotypic characteristics. Here we report the complete genome sequence of M. bovis BCG Moreau, the strain in continuous use in Brazil for vaccine production since the 1920s.

Citing Articles

The whole genome sequence of Polish vaccine strain BCG Moreau.

Krysztopa-Grzybowska K, Lach J, Polak M, Strapagiel D, Dziadek J, Olszewski M Microbiol Spectr. 2024; 12(7):e0425923.

PMID: 38757975 PMC: 11237378. DOI: 10.1128/spectrum.04259-23.

Differences in responses to the intracellular macrophage environment between Mycobacterium bovis BCG vaccine strains Moreau and Pasteur.

Correa P, Schwarz M, Maia R, Vergara F, Moraes M, Mendonca-Lima L Mem Inst Oswaldo Cruz. 2023; 118:e230070.

PMID: 37851722 PMC: 10581373. DOI: 10.1590/0074-02760230070.

Impact of Genomic Deletion RD16 on the Expression of the BCG Moreau VapBC47 Toxin-Antitoxin System.

Pagani T, Correa P, Lima C, Gomes L, Schwarz M, Galvao T Curr Issues Mol Biol. 2023; 45(8):6538-6549.

PMID: 37623231 PMC: 10453824. DOI: 10.3390/cimb45080412.

BCG Moreau N-Terminal Loss Leads to a Less Stable Dodecin With Lower Flavin Binding Capacity.

Schwarz M, Luzes B, Correa P, da Silva-Goncalves A, Machado L, Guimaraes A Front Cell Infect Microbiol. 2021; 11:658888.

PMID: 33869088 PMC: 8044443. DOI: 10.3389/fcimb.2021.658888.

Phenotypic and Genotypic Drug Susceptibility Assessment of Bacillus Calmette-Guérin Clinical Strains.

Sisco M, Gomes da Silva M, Distasio de Carvalho L, Dias Campos C, Caldas P, Lopez B Infect Drug Resist. 2021; 14:459-466.

PMID: 33574685 PMC: 7872933. DOI: 10.2147/IDR.S248096.

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