Mitochondrial Heterogeneity and Adaptations to Cellular Needs

Overview

Journal Nat Cell Biol

Specialty Cell Biology

Date 2024 May 16

PMID 38755301

Authors

Melia Granath-Panelo

Shingo Kajimura

Affiliations

Soon will be listed here.

Abstract

Although it is well described that mitochondria are at the epicentre of the energy demands of a cell, it is becoming important to consider how each cell tailors its mitochondrial composition and functions to suit its particular needs beyond ATP production. Here we provide insight into mitochondrial heterogeneity throughout development as well as in tissues with specific energy demands and discuss how mitochondrial malleability contributes to cell fate determination and tissue remodelling.

Citing Articles

Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus.

Xian Y, Liu B, Shen T, Yang L, Peng R, Shen H Bone Res. 2025; 13(1):30.

PMID: 40025004 PMC: 11873136. DOI: 10.1038/s41413-024-00399-5.

A Quantitative Approach to Mapping Mitochondrial Specialization and Plasticity.

Picard M, Monzel A, Devine J, Kapri D, Enriquez J, Trumpff C Res Sq. 2025; .

PMID: 39989954 PMC: 11844627. DOI: 10.21203/rs.3.rs-5961609/v1.

A Quantitative Approach to Mapping Mitochondrial Specialization and Plasticity.

Monzel A, Devine J, Kapri D, Enriquez J, Trumpff C, Picard M bioRxiv. 2025; .

PMID: 39975232 PMC: 11838522. DOI: 10.1101/2025.02.03.635951.

Single-cell atlas reveals multi-faced responses of losartan on tubular mitochondria in diabetic kidney disease.

Zhu Z, Luan G, Wu S, Song Y, Shen S, Wu K J Transl Med. 2025; 23(1):90.

PMID: 39838394 PMC: 11748887. DOI: 10.1186/s12967-025-06074-5.

Complete Mitogenomes of Xinjiang Hares and Their Selective Pressure Considerations.

Wang R, Tursun M, Shan W Int J Mol Sci. 2024; 25(22).

PMID: 39595994 PMC: 11593953. DOI: 10.3390/ijms252211925.

References

Spinelli J, Haigis M . The multifaceted contributions of mitochondria to cellular metabolism. Nat Cell Biol. 2018; 20(7):745-754. PMC: 6541229. DOI: 10.1038/s41556-018-0124-1. View

Bahat A, Gross A . Mitochondrial plasticity in cell fate regulation. J Biol Chem. 2019; 294(38):13852-13863. PMC: 6755789. DOI: 10.1074/jbc.REV118.000828. View

Mehta M, Weinberg S, Chandel N . Mitochondrial control of immunity: beyond ATP. Nat Rev Immunol. 2017; 17(10):608-620. DOI: 10.1038/nri.2017.66. View

Fecher C, Trovo L, Muller S, Snaidero N, Wettmarshausen J, Heink S . Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity. Nat Neurosci. 2019; 22(10):1731-1742. DOI: 10.1038/s41593-019-0479-z. View

Kajimura S, Saito M . A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis. Annu Rev Physiol. 2013; 76:225-49. PMC: 4090362. DOI: 10.1146/annurev-physiol-021113-170252. View

Yook J, Taxin Z, Yuan B, Oikawa S, Auger C, Mutlu B . The SLC25A47 locus controls gluconeogenesis and energy expenditure. Proc Natl Acad Sci U S A. 2023; 120(9):e2216810120. PMC: 9992842. DOI: 10.1073/pnas.2216810120. View

Lesner N, Wang X, Chen Z, Frank A, Menezes C, House S . Differential requirements for mitochondrial electron transport chain components in the adult murine liver. Elife. 2022; 11. PMC: 9648974. DOI: 10.7554/eLife.80919. View

Diaz-Cuadros M, Miettinen T, Skinner O, Sheedy D, Diaz-Garcia C, Gapon S . Metabolic regulation of species-specific developmental rates. Nature. 2023; 613(7944):550-557. PMC: 9944513. DOI: 10.1038/s41586-022-05574-4. View

Burr S, Klimm F, Glynos A, Prater M, Sendon P, Nash P . Cell lineage-specific mitochondrial resilience during mammalian organogenesis. Cell. 2023; 186(6):1212-1229.e21. DOI: 10.1016/j.cell.2023.01.034. View

10.

Huppertz I, Perez-Perri J, Mantas P, Sekaran T, Schwarzl T, Russo F . Riboregulation of Enolase 1 activity controls glycolysis and embryonic stem cell differentiation. Mol Cell. 2022; 82(14):2666-2680.e11. DOI: 10.1016/j.molcel.2022.05.019. View

11.

Gu W, Gaeta X, Sahakyan A, Chan A, Hong C, Kim R . Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State. Cell Stem Cell. 2016; 19(4):476-490. PMC: 5055460. DOI: 10.1016/j.stem.2016.08.008. View

12.

Xu X, Duan S, Yi F, Ocampo A, Liu G, Izpisua Belmonte J . Mitochondrial regulation in pluripotent stem cells. Cell Metab. 2013; 18(3):325-32. DOI: 10.1016/j.cmet.2013.06.005. View

13.

Hicks M, Pyle A . The emergence of the stem cell niche. Trends Cell Biol. 2022; 33(2):112-123. PMC: 9868094. DOI: 10.1016/j.tcb.2022.07.003. View

14.

Mohyeldin A, Garzon-Muvdi T, Quinones-Hinojosa A . Oxygen in stem cell biology: a critical component of the stem cell niche. Cell Stem Cell. 2010; 7(2):150-61. DOI: 10.1016/j.stem.2010.07.007. View

15.

Justino de Almeida M, Luchsinger L, Corrigan D, Williams L, Snoeck H . Dye-Independent Methods Reveal Elevated Mitochondrial Mass in Hematopoietic Stem Cells. Cell Stem Cell. 2017; 21(6):725-729.e4. PMC: 5728653. DOI: 10.1016/j.stem.2017.11.002. View

16.

Anso E, Weinberg S, Diebold L, Thompson B, Malinge S, Schumacker P . The mitochondrial respiratory chain is essential for haematopoietic stem cell function. Nat Cell Biol. 2017; 19(6):614-625. PMC: 5474760. DOI: 10.1038/ncb3529. View

17.

Chakrabarty R, Chandel N . Mitochondria as Signaling Organelles Control Mammalian Stem Cell Fate. Cell Stem Cell. 2021; 28(3):394-408. PMC: 7944920. DOI: 10.1016/j.stem.2021.02.011. View

18.

Zhang H, Badur M, Divakaruni A, Parker S, Jager C, Hiller K . Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions. Cell Rep. 2016; 16(6):1536-1547. PMC: 4981511. DOI: 10.1016/j.celrep.2016.06.102. View

19.

Zhu Q, An Y, Scherer P . Mitochondrial regulation and white adipose tissue homeostasis. Trends Cell Biol. 2021; 32(4):351-364. PMC: 8918005. DOI: 10.1016/j.tcb.2021.10.008. View

20.

Kladnicka I, cedikova M, Kripnerova M, Dvorakova J, Kohoutova M, Tuma Z . Mitochondrial respiration of adipocytes differentiating from human mesenchymal stem cells derived from adipose tissue. Physiol Res. 2020; 68(Suppl 3):S287-S296. DOI: 10.33549/physiolres.934353. View