» Articles » PMID: 38747733

The Protective Role of Endothelial GLUT1 in Ischemic Stroke

Overview
Journal Brain Behav
Specialty Psychology
Date 2024 May 15
PMID 38747733
Authors
Affiliations
Soon will be listed here.
Abstract

Objective: To provide thorough insight on the protective role of endothelial glucose transporter 1 (GLUT1) in ischemic stroke.

Methods: We comprehensively review the role of endothelial GLUT1 in ischemic stroke by narrating the findings concerning biological characteristics of GLUT1 in brain in depth, summarizing the changes of endothelial GLUT1 expression and activity during ischemic stroke, discussing how GLUT1 achieves its neuroprotective effect via maintaining endothelial function, and identifying some outstanding blind spots in current studies.

Results: Endothelial GLUT1 maintains persistent high glucose and energy requirements of the brain by transporting glucose through the blood-brain barrier, which preserves endothelial function and is beneficial to stroke prognosis.

Conclusion: This review underscores the potential involvement of GLUT1 trafficking, activity modulation, and degradation, and we look forward to more clinical and animal studies to illuminate these mechanisms.

Citing Articles

The protective role of endothelial GLUT1 in ischemic stroke.

Peng Q, Zeng W Brain Behav. 2024; 14(5):e3536.

PMID: 38747733 PMC: 11095318. DOI: 10.1002/brb3.3536.

References
1.
Shah K, Boreddy P, Abbruscato T . Nicotine pre-exposure reduces stroke-induced glucose transporter-1 activity at the blood-brain barrier in mice. Fluids Barriers CNS. 2015; 12:10. PMC: 4425877. DOI: 10.1186/s12987-015-0005-y. View

2.
Billinger S, Sisante J, Mattlage A, Alqahtani A, Abraham M, Rymer M . The relationship of pro-inflammatory markers to vascular endothelial function after acute stroke. Int J Neurosci. 2016; 127(6):486-492. PMC: 5186336. DOI: 10.1080/00207454.2016.1198344. View

3.
Hamilton B, Nichols R, Tsukamoto H, Boado R, Pardridge W, Rigby W . hnRNP A2 and hnRNP L bind the 3'UTR of glucose transporter 1 mRNA and exist as a complex in vivo. Biochem Biophys Res Commun. 1999; 261(3):646-51. DOI: 10.1006/bbrc.1999.1040. View

4.
Miranda K, Nagasawa H, Toscano J . Donors of HNO. Curr Top Med Chem. 2005; 5(7):649-64. DOI: 10.2174/1568026054679290. View

5.
Dirnagl U, Iadecola C, Moskowitz M . Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 1999; 22(9):391-7. DOI: 10.1016/s0166-2236(99)01401-0. View