Concurrent Stage III Unresectable Duodenal Adenocarcinoma and Metastatic Gastrointestinal Stromal Tumor Treated With Combination of Imatinib and MFOLFIRI

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2024 May 15

PMID 38745800

Authors

Amith Rao

Rohit Rao

Megan K Taylor

Mohammad Khreiss

Junaid Arshad

Affiliations

Soon will be listed here.

Abstract

Cases of concurrent duodenal adenocarcinoma and gastrointestinal stromal tumors (GISTs) are rare, and only a few have been reported. While some cases of other synchronous primary tumors with GIST have been reported, no shared mutations have been consistently found, creating challenges in selecting chemotherapy in cases of inoperable tumors. Here, we presented a case of a stage IIIA locally advanced/unresectable duodenal adenocarcinoma with concurrent metastatic small bowel GIST successfully being treated with combined imatinib and modified folinic acid, 5-fluorouracil, and irinotecan (mFOLFIRI) regimen.

References

Omeroglu S, Gulmez S, Bozkurt E . The first case: acute abdomen due to gastric gastrointestinal stromal tumor perforation with synchronous renal cell carcinoma. Ann Ital Chir. 2022; 11. View

Namikawa T, Maeda M, Yokota K, Tanioka N, Iwabu J, Munekage M . Laparoscopic Distal Gastrectomy for Synchronous Gastric Cancer and Gastrointestinal Stromal Tumor With Situs Inversus Totalis. In Vivo. 2021; 35(2):913-918. PMC: 8045063. DOI: 10.21873/invivo.12331. View

Kocer M, Muallaoglu S, Cetin B, Coskun H, Karahan N, Gurdal O . Second Primary Tumors in Patients with Gastrointestinal Stromal Tumors: A Single-Center Experience. Medicina (Kaunas). 2021; 57(5). PMC: 8153290. DOI: 10.3390/medicina57050494. View

He J, Ding K, Zheng L, Xu J, Li J, Wu Y . Adenosquamous carcinoma of the uncinate process of the pancreas with synchronous gastrointestinal stromal tumor of the stomach: Case report and review of the literature. Oncol Lett. 2012; 4(6):1191-1194. PMC: 3506715. DOI: 10.3892/ol.2012.902. View

Tournigand C, Andre T, Achille E, Lledo G, Flesh M, Mery-Mignard D . FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol. 2003; 22(2):229-37. DOI: 10.1200/JCO.2004.05.113. View

Makris E, Sharma A, Bergstrom E, Xu X, de la Torre J, Banerjee S . Synchronous, Yet Genomically Distinct, GIST Offer New Insights Into Precise Targeting of Tumor Driver Mutations. JCO Precis Oncol. 2021; 5. PMC: 8232556. DOI: 10.1200/PO.20.00384. View

Cassidy J, Tabernero J, Twelves C, Brunet R, Butts C, Conroy T . XELOX (capecitabine plus oxaliplatin): active first-line therapy for patients with metastatic colorectal cancer. J Clin Oncol. 2004; 22(11):2084-91. DOI: 10.1200/JCO.2004.11.069. View

Kelly C, Gutierrez Sainz L, Chi P . The management of metastatic GIST: current standard and investigational therapeutics. J Hematol Oncol. 2021; 14(1):2. PMC: 7786896. DOI: 10.1186/s13045-020-01026-6. View

Tsukamoto Y, Oshima H, Katsumori T, Hamaguchi H, Yamamoto S, Iwanaga T . [A Case of Small Intestinal Gastrointestinal Stromal Tumor(GIST)with Synchronous Colonic Cancer and Gastric Cancer at a Different Time]. Gan To Kagaku Ryoho. 2017; 43(12):2112-2114. View

10.

Michael M, Zalcberg J, Gibbs P, Lipton L, Gouillou M, Jefford M . A phase I trial of imatinib in combination with mFOLFOX6-bevacizumab in patients with advanced colorectal cancer. Cancer Chemother Pharmacol. 2012; 71(2):321-30. DOI: 10.1007/s00280-012-2009-5. View

11.

Hoehler T, von Wichert G, Schimanski C, Kanzler S, Moehler M, Hinke A . Phase I/II trial of capecitabine and oxaliplatin in combination with bevacizumab and imatinib in patients with metastatic colorectal cancer: AIO KRK 0205. Br J Cancer. 2013; 109(6):1408-13. PMC: 3776974. DOI: 10.1038/bjc.2013.409. View

12.

Xu H, Zhou S, Hu Q, Cao D . Apatinib treatment for unresectable gastrointestinal stromal tumor with synchronous gastric cancer. Precis Clin Med. 2022; 3(1):67-70. PMC: 8985806. DOI: 10.1093/pcmedi/pbaa005. View

13.

Szczepaniak K, Nasierowska-Guttmejer A . The occurrence of gastrointestinal stromal tumors with second malignancies - Case series of a single institution experience. Pathol Res Pract. 2021; 228:153662. DOI: 10.1016/j.prp.2021.153662. View

14.

Courelli A, Sharma A, Madlensky L, Choi Y, Li S, Sarno S . Co-Localization of Gastrointestinal Stromal Tumors (GIST) and Peritoneal Mesothelioma: A Case Series. Ann Surg Oncol. 2022; 29(12):7542-7548. PMC: 10226389. DOI: 10.1245/s10434-022-12211-x. View

15.

Diamantis A, Samara A, Baloyiannis I, Symeonidis D, Diamantis A, Tolia M . Gastrointestinal Stromal Tumor (GIST) and Synchronous Intra-Abdominal Liposarcoma: A Report of Two Rare Cases and Literature Review. Int J Surg Oncol. 2021; 2021:2626635. PMC: 8434899. DOI: 10.1155/2021/2626635. View

16.

Gregorio P, Takemura L, Vilela Galvao A, Gagliotti G, Edelmuth R, Segatelli V . Synchronous gallbladder adenocarcinoma and gastric gastrointestinal stromal tumor: Case report and literature review. Int J Surg Case Rep. 2019; 56:25-28. PMC: 6393670. DOI: 10.1016/j.ijscr.2019.02.001. View

17.

Ma J, Zhu J, Yu S, Zhou C, Duan S, Zhang Y . An ileal gastrointestinal stromal tumor misdiagnosed as pelvic metastases from rectal cancer: a case report. Front Oncol. 2023; 13:1164391. PMC: 10166831. DOI: 10.3389/fonc.2023.1164391. View

18.

Wu T, Wan J, Xia K, Yang M, Feng L, Yin L . Case Report: Next-Generation Sequencing-Based Detection in A Patient with Three Synchronous Primary Tumors. Front Oncol. 2022; 12:910264. PMC: 9334672. DOI: 10.3389/fonc.2022.910264. View

19.

Hou Q, Zhang W, Niu J, Tian M, Liu J, Cui L . Synchronous occurrence of gastrointestinal stromal tumor, pancreatic intraductal papillary mucinous neoplasm, and intrahepatic cholangiocarcinoma: Case report. Medicine (Baltimore). 2022; 101(28):e29460. PMC: 11139464. DOI: 10.1097/MD.0000000000029460. View