Case Report: Next-Generation Sequencing-Based Detection in A Patient with Three Synchronous Primary Tumors

Overview

Journal Front Oncol

Specialty Oncology

Date 2022 Aug 1

PMID 35912179

Authors

Tianqi Wu

Jian Wan

Kai Xia

Muqing Yang

Lijin Feng

Lu Yin

Chunqiu Chen

Affiliations

Soon will be listed here.

Abstract

Clinically rare, multiple primary tumors are a growth or development of two or more neoplasms in the same individual. A 57-year-old woman with two primary cancers, namely, breast and gastric cancers, and a gastrointestinal stromal tumor was admitted. Next-generation sequencing (NGS) of the three tumors and blood was performed to determine their clonal origin and identify genetic cancer susceptibility. NGS identified that germline genetic variants potentially correlated with an individual risk of developing multiple cancers and that additional mutations are required to drive the formation of different tumors.

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