Interleukin 2-induced Proliferation of Leukemic Human B Cells

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1985 May 1

PMID 3872922

Citations 17

Authors

O Lantz

C Grillot-Courvalin

C Schmitt

J P Fermand

J C Brouet

Affiliations

Soon will be listed here.

Abstract

The proliferative responses of purified leukemic human B cells from nine B cell chronic lymphocytic leukemias to recombinant interleukin 2 (IL-2), spontaneously, and after preactivation by Staphylococcus aureus Cowan I (SAC) or anti-mu antibodies were studied. Three patterns of response were observed: (a) no response (three cases); (b) a moderate spontaneous response enhanced by anti-mu (one case); (c) a high proliferative response after preactivation by anti-mu and/or SAC (five cases). IL-2 could also trigger normal B cells, purified from spleen, to proliferative after preactivation by anti-mu or SAC. These results provide evidence that IL-2 is a lymphokine that acts physiologically on both B and T cells.

Citing Articles

Growth and survival of B-chronic lymphocytic leukaemia cells.

Soderberg O Med Oncol. 1998; 15(2):73-8.

PMID: 9789213 DOI: 10.1007/BF02989583.

Sex hormones and immune dysregulation in multiple myeloma.

Everaus H, Lehtmaa J Cancer Immunol Immunother. 1993; 36(3):205-9.

PMID: 8439982 PMC: 11038210. DOI: 10.1007/BF01741093.

Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes.

Fluckiger A, Garrone P, Durand I, Galizzi J, Banchereau J J Exp Med. 1993; 178(5):1473-81.

PMID: 8228801 PMC: 2191252. DOI: 10.1084/jem.178.5.1473.

Membrane-bound and soluble IL-2 receptors (p55 and p75 chains) on peripheral blood mononuclear cells from patients with solid malignancies.

Mantovani G, Maccio A, Astara G, Contini L, Esu S, Littera S Cell Biophys. 1993; 22(1-3):79-99.

PMID: 7889544 DOI: 10.1007/BF03033868.

Membrane-bound/soluble IL-2 receptor (IL-2R) and levels of IL-1 alpha, IL-2, and IL-6 in the serum and in the PBMC culture supernatants from 17 patients with hematological malignancies.

Mantovani G, Maccio A, Lai P, Ghiani M, Turnu E, DEL GIACCO G Cell Biophys. 1995; 27(1):1-14.

PMID: 7493395 DOI: 10.1007/BF02822523.

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