Anti-Hu Antibody Associated Paraneoplastic Neurological Syndrome in a Child with Ganglioneuroblastoma: A Rare Case Report and Literature Review

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2024 May 10

PMID 38728479

Authors

Yi-Ling Dai

Ling Xiao

Zhen Pan

Guo-Qian He

Ju Gao

Xia Guo

Zhuo Huang

Affiliations

Soon will be listed here.

Abstract

Rationale: Paraneoplastic neurological syndrome with anti-Hu antibody (Hu-PNS) is a neurological disorder that occur in patients with malignancy. The syndrome has a wide range of presentations and can present before diagnosis of primary malignancy. Familiarity with these paraneoplastic neurological syndromes can help early recognition and take appropriate regimens.

Patients Concerns: Diagnosis and treatment of Hu-PNS.

Diagnoses: This is retrospective study that analyzed the clinical data of this case. Through retrospective analysis and targeted antibody screening, serum anti-Hu antibody was detected. Subsequent spinal imaging revealed a mass in the paraspinal region, which was confirmed as ganglioneuroblastoma by pathologic examination.

Interventions: The child was treated with a course of intravenous immunoglobulin and radical surgical operation without chemotherapy.

Outcomes: The neurological symptoms were gradually improved and no signs indicate disease progression or tumor recurrence.

Lessons: Hu-PNS has rarely been reported in children with ganglioneuroblastomas. They can mimic non-neoplastic processes, making detection and diagnosis difficult. Serum and/or cerebrospinal fluid onconeural antibody can strongly indicate occult cancers. Early detection of paraneoplastic neurological syndromes can help take appropriate regimens and improve prognosis.

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