Circadian Coordination: Understanding Interplay Between Circadian Clock and Mitochondria

Overview

Journal Anim Cells Syst (Seoul)

Specialty Biology

Date 2024 May 9

PMID 38721230

Authors

Jeongah Kim

Woong Sun

Affiliations

Soon will be listed here.

Abstract

Biological rhythms play a crucial role in temporally regulating behavioral, physiological, and cellular processes within our bodies. One prominent example is the circadian rhythm, which enables our bodies to anticipate external cues and regulate our internal processes accordingly. The circadian rhythm is controlled by a molecular feedback loop known as the circadian clock, present in nearly all cells. The regulation of genes involved in mitochondrial function is no exception. Key aspects such as oxidative phosphorylation, mitochondrial biogenesis, and mitochondrial morphology are regulated by the circadian clock. Functional changes in mitochondria can retrogradely affect the circadian rhythm. Furthermore, there are also transcriptional circadian clock-independent rhythms within mitochondria. This review discusses mitochondrial rhythms independently or in communication with the circadian clock in the nucleus at the cellular level.

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References

Chen L, Qin Y, Liu B, Gao M, Li A, Li X . PGC-1-Mediated Mitochondrial Quality Control: Molecular Mechanisms and Implications for Heart Failure. Front Cell Dev Biol. 2022; 10:871357. PMC: 9199988. DOI: 10.3389/fcell.2022.871357. View

Kohsaka A, Das P, Hashimoto I, Nakao T, Deguchi Y, Gouraud S . The circadian clock maintains cardiac function by regulating mitochondrial metabolism in mice. PLoS One. 2014; 9(11):e112811. PMC: 4229239. DOI: 10.1371/journal.pone.0112811. View

Liu C, Li S, Liu T, Borjigin J, Lin J . Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism. Nature. 2007; 447(7143):477-81. DOI: 10.1038/nature05767. View

Takahashi J . Transcriptional architecture of the mammalian circadian clock. Nat Rev Genet. 2016; 18(3):164-179. PMC: 5501165. DOI: 10.1038/nrg.2016.150. View

Xu L, Lin J, Liu Y, Hua B, Cheng Q, Lin C . CLOCK regulates Drp1 mRNA stability and mitochondrial homeostasis by interacting with PUF60. Cell Rep. 2022; 39(2):110635. DOI: 10.1016/j.celrep.2022.110635. View

Lamia K, Sachdeva U, DiTacchio L, Williams E, Alvarez J, Egan D . AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science. 2009; 326(5951):437-40. PMC: 2819106. DOI: 10.1126/science.1172156. View

Ulgherait M, Chen A, McAllister S, Kim H, Delventhal R, Wayne C . Circadian regulation of mitochondrial uncoupling and lifespan. Nat Commun. 2020; 11(1):1927. PMC: 7174288. DOI: 10.1038/s41467-020-15617-x. View

Luck S, Thurley K, Thaben P, Westermark P . Rhythmic degradation explains and unifies circadian transcriptome and proteome data. Cell Rep. 2014; 9(2):741-51. DOI: 10.1016/j.celrep.2014.09.021. View

Reinke H, Asher G . Crosstalk between metabolism and circadian clocks. Nat Rev Mol Cell Biol. 2019; 20(4):227-241. DOI: 10.1038/s41580-018-0096-9. View

10.

Asher G, Gatfield D, Stratmann M, Reinke H, Dibner C, Kreppel F . SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell. 2008; 134(2):317-28. DOI: 10.1016/j.cell.2008.06.050. View

11.

Nakahata Y, Kaluzova M, Grimaldi B, Sahar S, Hirayama J, Chen D . The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell. 2008; 134(2):329-40. PMC: 3526943. DOI: 10.1016/j.cell.2008.07.002. View

12.

Reddy A, Karp N, Maywood E, Sage E, Deery M, ONeill J . Circadian orchestration of the hepatic proteome. Curr Biol. 2006; 16(11):1107-15. DOI: 10.1016/j.cub.2006.04.026. View

13.

Bray M, Shaw C, Moore M, Garcia R, Zanquetta M, Durgan D . Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression. Am J Physiol Heart Circ Physiol. 2007; 294(2):H1036-47. DOI: 10.1152/ajpheart.01291.2007. View

14.

Mauvoisin D, Wang J, Jouffe C, Martin E, Atger F, Waridel P . Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver. Proc Natl Acad Sci U S A. 2013; 111(1):167-72. PMC: 3890886. DOI: 10.1073/pnas.1314066111. View

15.

Koike N, Yoo S, Huang H, Kumar V, Lee C, Kim T . Transcriptional architecture and chromatin landscape of the core circadian clock in mammals. Science. 2012; 338(6105):349-54. PMC: 3694775. DOI: 10.1126/science.1226339. View

16.

Neufeld-Cohen A, Robles M, Aviram R, Manella G, Adamovich Y, Ladeuix B . Circadian control of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins. Proc Natl Acad Sci U S A. 2016; 113(12):E1673-82. PMC: 4812734. DOI: 10.1073/pnas.1519650113. View

17.

ONeill J, Reddy A . Circadian clocks in human red blood cells. Nature. 2011; 469(7331):498-503. PMC: 3040566. DOI: 10.1038/nature09702. View

18.

Edgar R, Green E, Zhao Y, van Ooijen G, Olmedo M, Qin X . Peroxiredoxins are conserved markers of circadian rhythms. Nature. 2012; 485(7399):459-64. PMC: 3398137. DOI: 10.1038/nature11088. View

19.

Sardon Puig L, Valera-Alberni M, Canto C, Pillon N . Circadian Rhythms and Mitochondria: Connecting the Dots. Front Genet. 2018; 9:452. PMC: 6187225. DOI: 10.3389/fgene.2018.00452. View

20.

Gabriel B, Altintas A, Smith J, Sardon-Puig L, Zhang X, Basse A . Disrupted circadian oscillations in type 2 diabetes are linked to altered rhythmic mitochondrial metabolism in skeletal muscle. Sci Adv. 2021; 7(43):eabi9654. PMC: 8528429. DOI: 10.1126/sciadv.abi9654. View