A Review of Single-cell Transcriptomics and Epigenomics Studies in Maternal and Child Health

Overview

Journal Epigenomics

Specialty Genetics

Date 2024 May 6

PMID 38709139

Authors

Chang Shu

Kelly Street

Carrie V Breton

Theresa M Bastain

Melissa L Wilson

Affiliations

Soon will be listed here.

Abstract

Single-cell sequencing technologies enhance our understanding of cellular dynamics throughout pregnancy. We outlined the workflow of single-cell sequencing techniques and reviewed single-cell studies in maternal and child health. We conducted a literature review of single cell studies on maternal and child health using PubMed. We summarized the findings from 16 single-cell atlases of the human and mammalian placenta across gestational stages and 31 single-cell studies on maternal exposures and complications including infection, obesity, diet, gestational diabetes, pre-eclampsia, environmental exposure and preterm birth. Single-cell studies provides insights on novel cell types in placenta and cell type-specific marks associated with maternal exposures and complications.

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