Older-aged C57BL/6 Mice Fed a Diet High in Saturated Fat and Sucrose for Ten Months Show Decreased Resilience to Aging

Overview

Journal Aging Pathobiol Ther

Date 2024 May 6

PMID 38706773

Authors

Chloe Johnson

Lida Zhu

Ruby Mangalindan

Jeremy Whitson

Maryia Sweetwyne

Ana P Valencia

David J Marcinek

Peter Rabinovitch

Warren Ladiges

Affiliations

Soon will be listed here.

Abstract

The ability to respond to physical stress that disrupts normal physiological homeostasis at an older age embraces the concept of resilience to aging. A physical stressor could be used to induce physiological responses that are age-related, since resilience declines with increasing age. Increased fat and sugar intake is a nutritional stress with a high prevalence of obesity in older people. In order to determine the effect of this type of diet on resilience to aging, 18-month-old C57BL/6J male mice were fed a diet high in saturated fat (lard) and sucrose (HFS) for ten months. At the end of the 10-month study, mice fed the HFS diet showed increased cognitive impairment, decreased cardiac function, decreased strength and agility, and increased severity of renal pathology compared to mice fed a rodent chow diet low in saturated fat and sucrose (LFS). The degree of response aligned with decreased resilience to the long-term adverse effects of the diet with characteristics of accelerated aging. This observation suggests additional studies could be conducted to investigate the relationship between an accelerated decline in resilience to aging and enhanced resilience to aging under different dietary conditions.

References

Lu Z, Wang H, Zhang X, Huang X, Jiang S, Li Y . High fat diet induces brain injury and neuronal apoptosis via down-regulating 3-β hydroxycholesterol 24 reductase (DHCR24). Cell Tissue Res. 2023; 393(3):471-487. DOI: 10.1007/s00441-023-03804-3. View

Milanovic Z, Pantelic S, Trajkovic N, Sporis G, Kostic R, James N . Age-related decrease in physical activity and functional fitness among elderly men and women. Clin Interv Aging. 2013; 8:549-56. PMC: 3665513. DOI: 10.2147/CIA.S44112. View

Yeomans M, Armitage R, Atkinson R, Francis H, Stevenson R . Habitual intake of fat and sugar is associated with poorer memory and greater impulsivity in humans. PLoS One. 2023; 18(8):e0290308. PMC: 10449134. DOI: 10.1371/journal.pone.0290308. View

Qilu Fang -, Qinglin Li -, Like Zhong -, Yajun Qi -, Wenxiu Xin -, Luo Fang - . Paeony attenuates high fat diet-induced kidney injury via inflammation inhibition. Pak J Pharm Sci. 2023; 36(4):1217-1225. View

Abu Bakar N, Ahmad A, Wan Musa W, Shahril M, Wan-Arfah N, Abdul Majid H . Association between a dietary pattern high in saturated fatty acids, dietary energy density, and sodium with coronary heart disease. Sci Rep. 2022; 12(1):13049. PMC: 9336144. DOI: 10.1038/s41598-022-17388-5. View

Schorr A, Carter C, Ladiges W . The potential use of physical resilience to predict healthy aging. Pathobiol Aging Age Relat Dis. 2018; 8(1):1403844. PMC: 5700501. DOI: 10.1080/20010001.2017.1403844. View

Ladiges W, Snyder J, Wilkinson E, Imai D, Snider T, Ge X . A New Preclinical Paradigm for Testing Anti-Aging Therapeutics. J Gerontol A Biol Sci Med Sci. 2017; 72(6):760-762. PMC: 6075196. DOI: 10.1093/gerona/glx019. View

Lei H, Huffman D, Salmon A, LeBrasseur N, Carter C, Richardson A . Resilience to aging is a heterogeneous characteristic defined by physical stressors. Aging Pathobiol Ther. 2022; 4(1):19-22. PMC: 9038086. DOI: 10.31491/apt.2022.03.076. View

Duffy C, Hofmeister J, Nixon J, Butterick T . High fat diet increases cognitive decline and neuroinflammation in a model of orexin loss. Neurobiol Learn Mem. 2018; 157:41-47. PMC: 6547825. DOI: 10.1016/j.nlm.2018.11.008. View

10.

Ladiges W, Ikeno Y, Niedernhofer L, McIndoe R, Ciol M, Ritchey J . The Geropathology Research Network: An Interdisciplinary Approach for Integrating Pathology Into Research on Aging. J Gerontol A Biol Sci Med Sci. 2015; 71(4):431-4. PMC: 5014185. DOI: 10.1093/gerona/glv079. View

11.

Darvas M, Mukherjee K, Lee A, Ladiges W . A Novel One-Day Learning Procedure for Mice. Curr Protoc Mouse Biol. 2020; 10(1):e68. DOI: 10.1002/cpmo.68. View

12.

Kirkland J, Stout M, Sierra F . Resilience in Aging Mice. J Gerontol A Biol Sci Med Sci. 2016; 71(11):1407-1414. PMC: 5865545. DOI: 10.1093/gerona/glw086. View

13.

Schreyer S, Wilson D, LeBoeuf R . C57BL/6 mice fed high fat diets as models for diabetes-accelerated atherosclerosis. Atherosclerosis. 1998; 136(1):17-24. DOI: 10.1016/s0021-9150(97)00165-2. View

14.

Jiang Z, Wang J, Imai D, Snider T, Klug J, Mangalindan R . Short term treatment with a cocktail of rapamycin, acarbose and phenylbutyrate delays aging phenotypes in mice. Sci Rep. 2022; 12(1):7300. PMC: 9067553. DOI: 10.1038/s41598-022-11229-1. View

15.

Batsis J, Zagaria A . Addressing Obesity in Aging Patients. Med Clin North Am. 2017; 102(1):65-85. PMC: 5724972. DOI: 10.1016/j.mcna.2017.08.007. View

16.

Laurentius T, Raffetseder U, Fellner C, Kob R, Nourbakhsh M, Floege J . High-fat diet-induced obesity causes an inflammatory microenvironment in the kidneys of aging Long-Evans rats. J Inflamm (Lond). 2019; 16:14. PMC: 6593534. DOI: 10.1186/s12950-019-0219-x. View

17.

Liang Z, Gong X, Ye R, Zhao Y, Yu J, Zhao Y . Long-Term High-Fat Diet Consumption Induces Cognitive Decline Accompanied by Tau Hyper-Phosphorylation and Microglial Activation in Aging. Nutrients. 2023; 15(1). PMC: 9823602. DOI: 10.3390/nu15010250. View

18.

Nickel K, Zhu L, Mangalindan R, Snyder J, Tucker M, Whitson J . Long-term treatment with Elamipretide enhances healthy aging phenotypes in mice. Aging Pathobiol Ther. 2022; 4(3):76-83. PMC: 9562127. DOI: 10.31491/apt.2022.09.089. View

19.

Wen J, Wang Y, Wang C, Yuan M, Chen F, Zou Q . Dietary High-Fat Promotes Cognitive Impairment by Suppressing Mitophagy. Oxid Med Cell Longev. 2023; 2023:4822767. PMC: 9884172. DOI: 10.1155/2023/4822767. View