Melatonin Improves Maternal Sleep Deprivation-induced Learning and Memory Impairment, Inflammation, and Synaptic Dysfunction in Murine Male Adult Offspring

Overview

Journal Brain Behav

Specialty Psychology

Date 2024 May 4

PMID 38702895

Authors

Yue-Ming Zhang

Ru-Meng Wei

Zong-Yin Li

Xue-Yan Li

Kai-Xuan Zhang

Yi-Jun Ge

Xiao-Yi Kong

Xue-Chun Liu

Gui-Hai Chen

Affiliations

Soon will be listed here.

Abstract

Introduction: Maternal sleep deprivation (MSD), which induces inflammation and synaptic dysfunction in the hippocampus, has been associated with learning and memory impairment in offspring. Melatonin (Mel) has been shown to have anti-inflammatory, antioxidant, and neuroprotective function. However, the beneficial effect of Mel on MSD-induced cognitive impairment and its mechanisms are unknown.

Methods: In the present study, adult offspring suffered from MSD were injected with Mel (20 mg/kg) once a day during postnatal days 61-88. The cognitive function was evaluated by the Morris water maze test. Levels of proinflammatory cytokines were examined by enzyme-linked immunosorbent assay. The mRNA and protein levels of synaptic plasticity associated proteins were examined using reverse transcription-polymerase chain reaction and western blotting.

Results: The results showed that MSD impaired learning and memory in the offspring mice. MSD increased the levels of interleukin (IL)-1creIL-6, and tumor necrosis factor-α and decreased the expression levels of brain-derived neurotrophic factor, tyrosine kinase receptor B, postsynaptic density protein-95, and synaptophysin in the hippocampus. Furthermore, Mel attenuated cognitive impairment and restored markers of inflammation and synaptic plasticity to control levels.

Conclusions: These findings indicated that Mel could ameliorate learning and memory impairment induced by MSD, and these beneficial effects were related to improvement in inflammation and synaptic dysfunction.

Citing Articles

The Role of Piromelatine on Peripheral and Hippocampal Insulin Resistance in Rat Offspring Exposed to Chronic Maternal Stress.

Ivanova N, Atanasova M, Terzieva D, Georgieva K, Tchekalarova J Int J Mol Sci. 2024; 25(13).

PMID: 39000130 PMC: 11241293. DOI: 10.3390/ijms25137022.

Melatonin improves maternal sleep deprivation-induced learning and memory impairment, inflammation, and synaptic dysfunction in murine male adult offspring.

Zhang Y, Wei R, Li Z, Li X, Zhang K, Ge Y Brain Behav. 2024; 14(5):e3515.

PMID: 38702895 PMC: 11069022. DOI: 10.1002/brb3.3515.

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