Electroacupuncture Modulates Abnormal Brain Connectivity After Ischemia Reperfusion Injury in Rats: A Graph Theory-based Approach

Overview

Journal Brain Behav

Specialty Psychology

Date 2024 May 3

PMID 38698583

Authors

Si-Si Li

Xiang-Xin Xing

Xu-Yun Hua

Yu-Wen Zhang

Jia-Jia Wu

Chun-Lei Shan

He Wang

Mou-Xiong Zheng

Jian-Guang Xu

Affiliations

Soon will be listed here.

Abstract

Background: Electroacupuncture (EA) has been shown to facilitate brain plasticity-related functional recovery following ischemic stroke. The functional magnetic resonance imaging technique can be used to determine the range and mode of brain activation. After stroke, EA has been shown to alter brain connectivity, whereas EA's effect on brain network topology properties remains unclear. An evaluation of EA's effects on global and nodal topological properties in rats with ischemia reperfusion was conducted in this study.

Methods And Results: There were three groups of adult male Sprague-Dawley rats: sham-operated group (sham group), middle cerebral artery occlusion/reperfusion (MCAO/R) group, and MCAO/R plus EA (MCAO/R + EA) group. The differences in global and nodal topological properties, including shortest path length, global efficiency, local efficiency, small-worldness index, betweenness centrality (BC), and degree centrality (DC) were estimated. Graphical network analyses revealed that, as compared with the sham group, the MCAO/R group demonstrated a decrease in BC value in the right ventral hippocampus and increased BC in the right substantia nigra, accompanied by increased DC in the left nucleus accumbens shell (AcbSh). The BC was increased in the right hippocampus ventral and decreased in the right substantia nigra after EA intervention, and MCAO/R + EA resulted in a decreased DC in left AcbSh compared to MCAO/R.

Conclusion: The results of this study provide a potential basis for EA to promote cognitive and motor function recovery after ischemic stroke.

Citing Articles

Electroacupuncture modulates abnormal brain connectivity after ischemia reperfusion injury in rats: A graph theory-based approach.

Li S, Xing X, Hua X, Zhang Y, Wu J, Shan C Brain Behav. 2024; 14(5):e3504.

PMID: 38698583 PMC: 11066419. DOI: 10.1002/brb3.3504.

References

Lessard A, Couture R . Modulation of cardiac activity by tachykinins in the rat substantia nigra. Br J Pharmacol. 2001; 134(8):1749-59. PMC: 1572893. DOI: 10.1038/sj.bjp.0704401. View

Han X, Jin H, Li K, Ning Y, Jiang L, Chen P . Acupuncture Modulates Disrupted Whole-Brain Network after Ischemic Stroke: Evidence Based on Graph Theory Analysis. Neural Plast. 2020; 2020:8838498. PMC: 7453235. DOI: 10.1155/2020/8838498. View

Zhang J, Li Z, Cao X, Zuo L, Wen W, Zhu W . Altered Prefrontal-Basal Ganglia Effective Connectivity in Patients With Poststroke Cognitive Impairment. Front Neurol. 2021; 11:577482. PMC: 7772311. DOI: 10.3389/fneur.2020.577482. View

Heo J, Nam H, Kim Y, Choi J, Kim B, Kim D . Pathophysiologic and Therapeutic Perspectives Based on Thrombus Histology in Stroke. J Stroke. 2020; 22(1):64-75. PMC: 7005358. DOI: 10.5853/jos.2019.03440. View

Li S, Xing X, Hua X, Zhang Y, Wu J, Shan C . Electroacupuncture modulates abnormal brain connectivity after ischemia reperfusion injury in rats: A graph theory-based approach. Brain Behav. 2024; 14(5):e3504. PMC: 11066419. DOI: 10.1002/brb3.3504. View

Shi M, Liu S, Chen H, Geng W, Yin X, Chen Y . Disrupted brain functional network topology in unilateral acute brainstem ischemic stroke. Brain Imaging Behav. 2020; 15(1):444-452. DOI: 10.1007/s11682-020-00353-z. View

Vahid-Ansari F, Albert P . Chronic Fluoxetine Induces Activity Changes in Recovery From Poststroke Anxiety, Depression, and Cognitive Impairment. Neurotherapeutics. 2017; 15(1):200-215. PMC: 5794702. DOI: 10.1007/s13311-017-0590-3. View

Aihara T, Shimokawa T, Ogawa T, Okada Y, Ishikawa A, Inoue Y . Resting-State Functional Connectivity Estimated With Hierarchical Bayesian Diffuse Optical Tomography. Front Neurosci. 2020; 14:32. PMC: 7005139. DOI: 10.3389/fnins.2020.00032. View

Choi M, Kim H, Nah H, Kang D . Digital Therapeutics: Emerging New Therapy for Neurologic Deficits after Stroke. J Stroke. 2019; 21(3):242-258. PMC: 6780014. DOI: 10.5853/jos.2019.01963. View

10.

Li X, Cai L, Jiang X, Liu X, Wang J, Yang T . Resting-State fMRI in Studies of Acupuncture. Evid Based Complement Alternat Med. 2021; 2021:6616060. PMC: 8009717. DOI: 10.1155/2021/6616060. View

11.

Fan D, Rich D, Holtzman T, Ruther P, Dalley J, Lopez A . A wireless multi-channel recording system for freely behaving mice and rats. PLoS One. 2011; 6(7):e22033. PMC: 3134473. DOI: 10.1371/journal.pone.0022033. View

12.

Pang R, Wang D, Chen T, Yang A, Yi L, Chen S . Reorganization of prefrontal network in stroke patients with dyskinesias: evidence from resting-state functional near-infrared spectroscopy. J Biophotonics. 2022; 15(7):e202200014. DOI: 10.1002/jbio.202200014. View

13.

Liu B, Chen J, Wang J, Liu X, Duan X, Shang X . Altered small-world efficiency of brain functional networks in acupuncture at ST36: a functional MRI study. PLoS One. 2012; 7(6):e39342. PMC: 3382219. DOI: 10.1371/journal.pone.0039342. View

14.

Zhu Y, Bai L, Liang P, Kang S, Gao H, Yang H . Disrupted brain connectivity networks in acute ischemic stroke patients. Brain Imaging Behav. 2016; 11(2):444-453. DOI: 10.1007/s11682-016-9525-6. View

15.

Kim Y, Kim S, Sin R, Pu Y, Ri G, Rim K . Study on the Cerebral Blood Flow Regulatory Features of Acupuncture at Acupoints of the Governor Vessel. Med Acupunct. 2018; 30(4):192-197. PMC: 6106755. DOI: 10.1089/acu.2018.1285. View

16.

Lu Q, Bai Q, Ren H, Zhu B, Jiang T, Peng C . Effectiveness and Predictors of Poor Prognosis Following Intravenous Thrombolysis in Patients with Wake-Up Ischemic Stroke Guided by Rapid MRI. Neuropsychiatr Dis Treat. 2022; 18:317-325. PMC: 8860628. DOI: 10.2147/NDT.S351524. View

17.

Chen L, Fan X, Li H, Ye C, Yu H, Gong H . Topological Reorganization of the Default Mode Network in Severe Male Obstructive Sleep Apnea. Front Neurol. 2018; 9:363. PMC: 6008385. DOI: 10.3389/fneur.2018.00363. View

18.

Kessner S, Schlemm E, Cheng B, Bingel U, Fiehler J, Gerloff C . Somatosensory Deficits After Ischemic Stroke. Stroke. 2019; 50(5):1116-1123. DOI: 10.1161/STROKEAHA.118.023750. View

19.

Xue X, Wu J, Huo B, Xing X, Ma J, Li Y . Age-related alterations of brain metabolic network based on [18F]FDG-PET of rats. Aging (Albany NY). 2022; 14(2):923-942. PMC: 8833125. DOI: 10.18632/aging.203851. View

20.

Yang G, Zhu J, Zhan G, Fan G, Deng L, Tang H . Mesenchymal Stem Cell-Derived Neuron-Like Cell Transplantation Combined with Electroacupuncture Improves Synaptic Plasticity in Rats with Intracerebral Hemorrhage via mTOR/p70S6K Signaling. Stem Cells Int. 2022; 2022:6450527. PMC: 8863490. DOI: 10.1155/2022/6450527. View