Comprehensive Overview of Different Medicinal Parts from L.: Chemical Compositions and Pharmacological Activities

Overview

Journal Front Pharmacol

Date 2024 May 2

PMID 38694910

Authors

Yumei Wang

Qing Ai

Meiling Gu

Hong Guan

Wenqin Yang

Meng Zhang

Jialin Mao

Zhao Lin

Qi Liu

Jicheng Liu

Affiliations

Soon will be listed here.

Abstract

L., a common traditional Chinese medicine (TCM) with a centuries-old medicinal history, owned various medicinal parts like Mori folium, Mori ramulus, Mori cortex and Mori fructus. Different medical parts exhibit distinct modern pharmacological effects. Mori folium exhibited analgesic, anti-inflammatory, hypoglycemic action and lipid-regulation effects. Mori ramulus owned anti-bacterial, anti-asthmatic and diuretic activities. Mori cortex showed counteraction action of pain, inflammatory, bacterial, and platelet aggregation. Mori fructus could decompose fat, lower blood lipids and prevent vascular sclerosis. The main chemical components in L. covered flavonoids, phenolic compounds, alkaloids, and amino acids. This article comprehensively analyzed the recent literature related to chemical components and pharmacological actions of L., summarizing 198 of ingredients and described the modern activities of different extracts and the bioactive constituents in the four parts from L. These results fully demonstrated the medicinal value of L., provided valuable references for further comprehensive development, and layed the foundation for the utilization of L.

References

Zhou H, Yan X, Yu W, Liang X, Du X, Liu Z . Lactic acid in macrophage polarization: The significant role in inflammation and cancer. Int Rev Immunol. 2021; 41(1):4-18. DOI: 10.1080/08830185.2021.1955876. View

Yang Q, Kang Z, Zhang J, Qu F, Song B . Neuroprotective Effects of Isoquercetin: An and Study. Cell J. 2021; 23(3):355-365. PMC: 8286454. DOI: 10.22074/cellj.2021.7116. View

Lee D, Yu J, Lee S, Hwang G, Kang K, Park J . Beneficial Effects of Bioactive Compounds in Mulberry Fruits against Cisplatin-Induced Nephrotoxicity. Int J Mol Sci. 2018; 19(4). PMC: 5979275. DOI: 10.3390/ijms19041117. View

Wei T, Ji X, Xue J, Gao Y, Zhu X, Xiao G . Cyanidin-3-O-glucoside represses tumor growth and invasion in vivo by suppressing autophagy via inhibition of the JNK signaling pathways. Food Funct. 2020; 12(1):387-396. DOI: 10.1039/d0fo02107e. View

Hsu J, Yang C, Chen J . Antioxidant, Anti-α-Glucosidase, Antityrosinase, and Anti-Inflammatory Activities of Bioactive Components from . Antioxidants (Basel). 2022; 11(11). PMC: 9686747. DOI: 10.3390/antiox11112222. View

Zeng Q, Chen M, Wang S, Xu X, Li T, Xiang Z . Comparative and phylogenetic analyses of the chloroplast genome reveal the taxonomy of the genus. Front Plant Sci. 2022; 13:1047592. PMC: 9729782. DOI: 10.3389/fpls.2022.1047592. View

Gao C, Sun X, Wu Z, Yuan H, Han H, Huang H . A Novel Benzofuran Derivative Moracin N Induces Autophagy and Apoptosis Through ROS Generation in Lung Cancer. Front Pharmacol. 2020; 11:391. PMC: 7235196. DOI: 10.3389/fphar.2020.00391. View

Lei L, Huan Y, Liu Q, Li C, Cao H, Ji W . L. (Sangzhi) Alkaloids Promote Insulin Secretion, Restore Diabetic β-Cell Function by Preventing Dedifferentiation and Apoptosis. Front Pharmacol. 2022; 13:841981. PMC: 8927674. DOI: 10.3389/fphar.2022.841981. View

Chen T, Shuang F, Fu Q, Ju Y, Zong C, Zhao W . Evaluation of the Chemical Composition and Antioxidant Activity of Mulberry ( L.) Fruits from Different Varieties in China. Molecules. 2022; 27(9). PMC: 9102544. DOI: 10.3390/molecules27092688. View

10.

Shu Y, Yuan H, Xu M, Hong Y, Gao C, Wu Z . A novel Diels-Alder adduct of mulberry leaves exerts anticancer effect through autophagy-mediated cell death. Acta Pharmacol Sin. 2020; 42(5):780-790. PMC: 8115316. DOI: 10.1038/s41401-020-0492-5. View

11.

Jeong J, Liu Q, Kim S, Jo Y, Mo E, Yang H . Characterization of Melanogenesis Inhibitory Constituents of Morus alba Leaves and Optimization of Extraction Conditions Using Response Surface Methodology. Molecules. 2015; 20(5):8730-41. PMC: 6272263. DOI: 10.3390/molecules20058730. View

12.

Lim D, Jung J, Park J, Baek N, Kim Y, Kim I . Antidepressant-Like Effects of Sanggenon G, Isolated from the Root Bark of Morus alba, in Rats: Involvement of the Serotonergic System. Biol Pharm Bull. 2015; 38(11):1772-8. DOI: 10.1248/bpb.b15-00471. View

13.

Kim J, Doh E, Lee G . Quantitative Comparison of the Marker Compounds in Different Medicinal Parts of L. Using High-Performance Liquid Chromatography-Diode Array Detector with Chemometric Analysis. Molecules. 2020; 25(23). PMC: 7730820. DOI: 10.3390/molecules25235592. View

14.

Ren B, Kwah M, Liu C, Ma Z, Shanmugam M, Ding L . Resveratrol for cancer therapy: Challenges and future perspectives. Cancer Lett. 2021; 515:63-72. DOI: 10.1016/j.canlet.2021.05.001. View

15.

Zhang L, Tao G, Chen J, Zheng Z . Characterization of a New Flavone and Tyrosinase Inhibition Constituents from the Twigs of Morus alba L. Molecules. 2016; 21(9). PMC: 6274457. DOI: 10.3390/molecules21091130. View

16.

Islam A, Islam M, Rahman M, Uddin M, Akanda M . The pharmacological and biological roles of eriodictyol. Arch Pharm Res. 2020; 43(6):582-592. DOI: 10.1007/s12272-020-01243-0. View

17.

Cha S, Kim H, Jang H, Lee J, Chao T, Baek N . Steppogenin suppresses tumor growth and sprouting angiogenesis through inhibition of HIF-1α in tumors and DLL4 activity in the endothelium. Phytomedicine. 2022; 108:154513. DOI: 10.1016/j.phymed.2022.154513. View

18.

Jia Y, He W, Zhang H, He L, Wang Y, Zhang T . Morusin Ameliorates IL-1β-Induced Chondrocyte Inflammation and Osteoarthritis via NF-κB Signal Pathway. Drug Des Devel Ther. 2020; 14:1227-1240. PMC: 7105369. DOI: 10.2147/DDDT.S244462. View

19.

Hyun J, Im J, Kim S, Kim H, Seo I, Bhang S . Root Extract Induces the Anagen Phase in the Human Hair Follicle Dermal Papilla Cells. Pharmaceutics. 2021; 13(8). PMC: 8399394. DOI: 10.3390/pharmaceutics13081155. View

20.

Plotnikov M, Plotnikova T . Tyrosol as a Neuroprotector: Strong Effects of a "Weak" Antioxidant. Curr Neuropharmacol. 2020; 19(4):434-448. PMC: 8206466. DOI: 10.2174/1570159X18666200507082311. View