Root Extract Induces the Anagen Phase in the Human Hair Follicle Dermal Papilla Cells

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2021 Aug 28

PMID 34452116

Citations 8

Authors

Jiyu Hyun

Jisoo Im

Sung-Won Kim

Han Young Kim

Inwoo Seo

Suk Ho Bhang

Affiliations

Soon will be listed here.

Abstract

Restoring hair follicles by inducing the anagen phase is a promising approach to prevent hair loss. Hair follicle dermal papilla cells (HFDPCs) play a major role in hair growth via the telogen-to-anagen transition. The therapeutic effect of activates β-catenin in HFDPCs, thereby inducing the anagen phase. The HFDPCs were treated with root extract (MARE) to promote hair growth. It contains chlorogenic acid and umbelliferone and is not cytotoxic to HFDPCs at a concentration of 20%. It was demonstrated that a small amount of MARE enhances growth factor secretion (related to the telogen-to-anagen transition). Activation of β-catenin was observed in MARE-treated HFDPCs, which is crucial for inducing the anagen phase. The effect of conditioned medium derived from MARE-treated HFDPCs on keratinocytes and endothelial cells was also investigated. The findings of this study demonstrate the potency of MARE in eliciting the telogen-to-anagen transition.

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