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Role and Limitation of Cell Therapy in Treating Neurological Diseases

Overview
Journal Ibrain
Specialty Neurology
Date 2024 Apr 29
PMID 38682022
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Abstract

The central role of the brain in governing systemic functions within human physiology underscores its paramount significance as the focal point of physiological regulation. The brain, a highly sophisticated organ, orchestrates a diverse array of physiological processes encompassing motor control, sensory perception, cognition, emotion, and the regulation of vital functions, such as heartbeat, respiration, and hormonal equilibrium. A notable attribute of neurological diseases manifests as the depletion of neurons and the occurrence of tissue necrosis subsequent to injury. The transplantation of neural stem cells (NSCs) into the brain exhibits the potential for the replacement of lost neurons and the reconstruction of neural circuits. Furthermore, the transplantation of other types of cells in alternative locations can secrete nutritional factors that indirectly contribute to the restoration of nervous system equilibrium and the mitigation of neural inflammation. This review summarized a comprehensive investigation into the role of NSCs, hematopoietic stem cells, mesenchymal stem cells, and support cells like astrocytes and microglia in alleviating neurological deficits after cell infusion. Moreover, a thorough assessment was undertaken to discuss extant constraints in cellular transplantation therapies, concurrently delineating indispensable model-based methodologies, specifically on organoids, which were essential for guiding prospective research initiatives in this specialized field.

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References
1.
Roth G, Dicke U . Origin and evolution of human cognition. Prog Brain Res. 2019; 250:285-316. DOI: 10.1016/bs.pbr.2019.02.004. View

2.
Austyn J . Dendritic cells. Curr Opin Hematol. 1998; 5(1):3-15. DOI: 10.1097/00062752-199801000-00002. View

3.
Du L, Lin L, Li Q, Liu K, Huang Y, Wang X . IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties. Cell Metab. 2019; 29(6):1363-1375.e8. DOI: 10.1016/j.cmet.2019.01.006. View

4.
Yang Z, Gong M, Jian T, Li J, Yang C, Ma Q . Engrafted glial progenitor cells yield long-term integration and sensory improvement in aged mice. Stem Cell Res Ther. 2022; 13(1):285. PMC: 9241208. DOI: 10.1186/s13287-022-02959-0. View

5.
Kanton S, Boyle M, He Z, Santel M, Weigert A, Sanchis-Calleja F . Organoid single-cell genomic atlas uncovers human-specific features of brain development. Nature. 2019; 574(7778):418-422. DOI: 10.1038/s41586-019-1654-9. View