Does High Dose Statin Pretreatment Affect Global Strains in Patients Undergoing Valve Replacement

Overview

Journal Indian J Thorac Cardiovasc Surg

Publisher Springer

Date 2024 Apr 29

PMID 38681712

Authors

Sudesh Prajapathi

Aditya Kapoor

Surendra Kumar Agarwal

Prabhat Tewari

Shantanu Pande

Bipin Chandra

Ankit Sahu

Roopali Khanna

Sudeep Kumar

Naveen Garg

Satyendra Tewari

Affiliations

Soon will be listed here.

Abstract

Purpose: To study the effect of rosuvastatin 40 mg (initiated 7 days prior to surgery) in patients undergoing valve replacement (VR) for rheumatic mitral valve disease on left ventricular (LV) strain and biomarker release kinetics.

Methods: In this randomized study, cardiac biomarkers viz. troponin I (TnI), Creatine kinase MB (CK-MB), N-terminal pro B-type natriuretic peptide (NTPBNP) were measured before surgery; and 8, 24 and 48 h postoperatively. Global LV (circumferential, global circumferential strain (GCS); longitudinal, GLS; radial, global radial strain (GRS)) strains were measured preoperatively; and 48 h and 30 days postoperatively.

Results: Following VR, Global Longitudinal Strain (GLS), Global Circumferential Strain (GCS) and Global Radial Strain (GRS) declined at 48 h in both statin loaded (SL) and non loaded (NL) groups. The (% change in GLS 35.8% vs 38.8%, GCS 34% vs 44.1%, GRS 45.7% vs 52.6%; p < 0.001). (GLS -15.92 ± 2.00% vs -12.6 ± 1.66%, GCS -15.12 ± 2.93% vs -13.04 ± 2.44%; GRS 22.12 ± 6.85% vs 19.32 ± 6.48%). at 8, 24 and 48 h were Mean change (baseline to peak biomarker value) was also significantly lower in SL group.The SL group had . On postoperative 30 day .

Conclusion: Pre-operative high dose rosuvastatin was "cardioprotective" with favorable effect on LV global strain and release kinetics of biomarkers. These cut-offs (described for the first time for rheumatic VR) can be used as prognostic predictors.

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