Role of Non-coding RNAs on the Radiotherapy Sensitivity and Resistance in Cancer Cells

Overview

Journal Curr Gene Ther

Publisher Bentham Science Publishers

Specialties Genetics
Pharmacology

Date 2024 Apr 27

PMID 38676526

Authors

Fatemeh Jalali-Zefrei

Seyed Mehdi Mousavi

Kourosh Delpasand

Mohammad Shourmij

Soghra Farzipour

Affiliations

Soon will be listed here.

Abstract

Radiotherapy (RT) is an integral part of treatment management in cancer patients. However, one of the limitations of this treatment method is the resistance of cancer cells to radiotherapy. These restrictions necessitate the introduction of modalities for the radiosensitization of cancer cells. It has been shown that Noncoding RNAs (ncRNAs), along with modifiers, can act as radiosensitivity and radioresistant regulators in a variety of cancers by affecting double strand break (DSB), wnt signaling, glycolysis, irradiation induced apoptosis, ferroptosis and cell autophagy. This review will provide an overview of the latest research on the roles and regulatory mechanisms of ncRNA after RT in and preclinical researches.

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