Role of P53 in Regulating Radiation Responses

Overview

Journal Life (Basel)

Specialty Biology

Date 2022 Jul 27

PMID 35888186

Authors

Ryuji Okazaki

Affiliations

Soon will be listed here.

Abstract

p53 is known as the guardian of the genome and plays various roles in DNA damage and cancer suppression. The gene was found to express multiple p53 splice variants (isoforms) in a physiological, tissue-dependent manner. The various genes that up- and down-regulated p53 are involved in cell viability, senescence, inflammation, and carcinogenesis. Moreover, p53 affects the radioadaptive response. Given that several studies have already been published on p53, this review presents its role in the response to gamma irradiation by interacting with MDM2, NF-κB, and miRNA, as well as in the inflammation processes, senescence, carcinogenesis, and radiation adaptive responses. Finally, the potential of p53 as a biomarker is discussed.

Citing Articles

Ionising radiation exposure-induced regulation of selected biomarkers and their impact in cancer and treatment.

Mzizi Y, Mbambara S, Moetlhoa B, Mahapane J, Mdanda S, Sathekge M Front Nucl Med. 2024; 4:1469897.

PMID: 39498386 PMC: 11532091. DOI: 10.3389/fnume.2024.1469897.

NEAT1 modulates the TIRR/53BP1 complex to maintain genome integrity.

Kilgas S, Syed A, Toolan-Kerr P, Swift M, Roychoudhury S, Sarkar A Nat Commun. 2024; 15(1):8438.

PMID: 39349456 PMC: 11443056. DOI: 10.1038/s41467-024-52862-w.

P53 and pRB induction improves response to radiation therapy in HPV-positive laryngeal squamous cell carcinoma.

Ding W, Cai W, Wang H Clinics (Sao Paulo). 2024; 79:100415.

PMID: 38897099 PMC: 11237859. DOI: 10.1016/j.clinsp.2024.100415.

Role of Non-coding RNAs on the Radiotherapy Sensitivity and Resistance in Cancer Cells.

Jalali-Zefrei F, Mousavi S, Delpasand K, Shourmij M, Farzipour S Curr Gene Ther. 2024; 25(2):113-135.

PMID: 38676526 DOI: 10.2174/0115665232301727240422092311.

Differential Gene Expression in Human Fibroblasts Simultaneously Exposed to Ionizing Radiation and Simulated Microgravity.

Malatesta P, Kyriakidis K, Hada M, Ikeda H, Takahashi A, Saganti P Biomolecules. 2024; 14(1).

PMID: 38254688 PMC: 10812944. DOI: 10.3390/biom14010088.

References

Horie K, Kubo K, Yonezawa M . p53 dependency of radio-adaptive responses in endogenous spleen colonies and peripheral blood-cell counts in C57BL mice. J Radiat Res. 2003; 43(4):353-60. DOI: 10.1269/jrr.43.353. View

Panganiban R, Day R . Inhibition of IGF-1R prevents ionizing radiation-induced primary endothelial cell senescence. PLoS One. 2013; 8(10):e78589. PMC: 3813482. DOI: 10.1371/journal.pone.0078589. View

Ghosh J, Suzuki K, Kodama S, Watanabe M . Effects of protein kinase inhibitors on the accumulation kinetics of p53 protein in normal human embryo cells following X-irradiation. J Radiat Res. 1999; 40(1):23-37. DOI: 10.1269/jrr.40.23. View

Okazaki R, Ootsuyama A, Norimura T . Radioadaptive response for protection against radiation-induced teratogenesis. Radiat Res. 2005; 163(3):266-70. DOI: 10.1667/rr3315. View

Wang Z, Mao J, Liu G, Wang F, Ju Z, Zhou D . MicroRNA-372 enhances radiosensitivity while inhibiting cell invasion and metastasis in nasopharyngeal carcinoma through activating the PBK-dependent p53 signaling pathway. Cancer Med. 2019; 8(2):712-728. PMC: 6382924. DOI: 10.1002/cam4.1924. View

MacLaren A, Black E, Clark W, Gillespie D . c-Jun-deficient cells undergo premature senescence as a result of spontaneous DNA damage accumulation. Mol Cell Biol. 2004; 24(20):9006-18. PMC: 517871. DOI: 10.1128/MCB.24.20.9006-9018.2004. View

Gudkov A, Komarova E . p53 and the Carcinogenicity of Chronic Inflammation. Cold Spring Harb Perspect Med. 2016; 6(11). PMC: 5088512. DOI: 10.1101/cshperspect.a026161. View

Mert U, Ozgur E, Tiryakioglu D, Dalay N, Gezer U . Induction of p53-inducible microRNA miR-34 by gamma radiation and bleomycin are different. Front Genet. 2012; 3:220. PMC: 3475997. DOI: 10.3389/fgene.2012.00220. View

Zheng G, Ravi A, Calabrese J, Medeiros L, Kirak O, Dennis L . A latent pro-survival function for the mir-290-295 cluster in mouse embryonic stem cells. PLoS Genet. 2011; 7(5):e1002054. PMC: 3088722. DOI: 10.1371/journal.pgen.1002054. View

10.

Igari K, Igari Y, Okazaki R, Kato F, Ootsuyama A, Norimura T . The delayed manifestation of T-cell receptor (TCR) variants in X-irradiated mice depends on Trp53 status. Radiat Res. 2006; 166(1 Pt 1):55-60. DOI: 10.1667/RR3583.1. View

11.

Rabes H . Gene rearrangements in radiation-induced thyroid carcinogenesis. Med Pediatr Oncol. 2001; 36(5):574-82. DOI: 10.1002/mpo.1133. View

12.

Jiang H, Li W, Li X, Cai L, Wang G . Low-dose radiation induces adaptive response in normal cells, but not in tumor cells: in vitro and in vivo studies. J Radiat Res. 2008; 49(3):219-30. DOI: 10.1269/jrr.07072. View

13.

He T, Guo J, Song H, Zhu H, Di X, Min H . Nutlin-3, an Antagonist of MDM2, Enhances the Radiosensitivity of Esophageal Squamous Cancer with Wild-Type p53. Pathol Oncol Res. 2017; 24(1):75-81. DOI: 10.1007/s12253-017-0215-5. View

14.

Kruiswijk F, Labuschagne C, Vousden K . p53 in survival, death and metabolic health: a lifeguard with a licence to kill. Nat Rev Mol Cell Biol. 2015; 16(7):393-405. DOI: 10.1038/nrm4007. View

15.

Habraken Y, Piette J . NF-kappaB activation by double-strand breaks. Biochem Pharmacol. 2006; 72(9):1132-41. DOI: 10.1016/j.bcp.2006.07.015. View

16.

Eliyahu D, Raz A, Gruss P, Givol D, Oren M . Participation of p53 cellular tumour antigen in transformation of normal embryonic cells. Nature. 1984; 312(5995):646-9. DOI: 10.1038/312646a0. View

17.

Jin Y, Burns J, Garte S, Hosselet S . Infrequent alterations of the p53 gene in rat skin cancers induced by ionizing radiation. Carcinogenesis. 1996; 17(4):873-6. DOI: 10.1093/carcin/17.4.873. View

18.

Puszynski K, Bertolusso R, Lipniacki T . Crosstalk between p53 and nuclear factor-B systems: pro- and anti-apoptotic functions of NF-B. IET Syst Biol. 2010; 3(5):356-67. DOI: 10.1049/iet-syb.2008.0172. View

19.

Balkwill F, Coussens L . Cancer: an inflammatory link. Nature. 2004; 431(7007):405-6. DOI: 10.1038/431405a. View

20.

McAllister K, Lorimore S, Wright E, Coates P . In vivo interactions between ionizing radiation, inflammation and chemical carcinogens identified by increased DNA damage responses. Radiat Res. 2012; 177(5):584-93. DOI: 10.1667/rr2690.1. View