Advances in Technologies for Highly Active Omega-3 Fatty Acids from Krill Oil: Clinical Applications

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2021 Jun 2

PMID 34073184

Citations 10

Authors

Alessandro Colletti

Giancarlo Cravotto

Valentina Citi

Alma Martelli

Lara Testai

Arrigo F G Cicero

Affiliations

Soon will be listed here.

Abstract

, commonly known as krill, is a small marine crustacean from the Antarctic Ocean that plays an important role in the marine ecosystem, serving as feed for most fish. It is a known source of highly bioavailable omega-3 polyunsaturated fatty acids (eicosapentaenoic acid and docosahexaenoic acid). In preclinical studies, krill oil showed metabolic, anti-inflammatory, neuroprotective and chemo preventive effects, while in clinical trials it showed significant metabolic, vascular and ergogenic actions. Solvent extraction is the most conventional method to obtain krill oil. However, different solvents must be used to extract all lipids from krill because of the diversity of the polarities of the lipid compounds in the biomass. This review aims to provide an overview of the chemical composition, bioavailability and bioaccessibility of krill oil, as well as the mechanisms of action, classic and non-conventional extraction techniques, health benefits and current applications of this marine crustacean.

Citing Articles

Comparison of Omega-3 polyunsaturated fatty acids bioavailability in fish oil and krill oil: Network Meta-analyses.

Pham T, Hoang T, Cao P, Le T, Ho V, Vu T Food Chem X. 2025; 24:101880.

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Krill oil for knee osteoarthritis: A meta-analysis of randomized controlled trials.

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Pilot-Scale Enzymatic Conversion of Low Stability, High Free Fatty, Squid Oil to an Oxidatively Stable Astaxanthin-Rich Acylglyceride Oil Suitable for Nutritional Applications.

Joshi A, Holland B, Sachar M, Barrow C Mar Drugs. 2025; 23(1.

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Comparison of Dietary Supplementation with Krill Oil, Fish Oil, and Astaxanthin on an Experimental Ethanol-Induced Gastric Ulcer Model: A Biochemical and Histological Study.

Sariyer E, Bas M, Colak H, Ozkan Yenal N, Unay Demirel O, Yuksel M Nutrients. 2024; 16(20).

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Does krill oil enhancing the new bone formation in orthopedically expanded median palatal suture in rat model? A micro-CT and immunohistochemical analysis.

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