Variation Among Human 28S Ribosomal RNA Genes

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1985 Nov 1

PMID 3865188

Citations 106

Authors

I L Gonzalez

J L Gorski

T J Campen

D J Dorney

J M Erickson

J E Sylvester

R D Schmickel

Affiliations

Soon will be listed here.

Abstract

We report the complete 5025-base sequence of the human 28S rRNA gene. Variability within the species has been demonstrated by sequencing a variable region from six separately cloned genes. This region is one of three large subunit rRNA regions that show extreme sequence and size variation among species. The interspecies differences suggest species-specific functions for these sections, while the intraspecies heterogeneity indicates differences among ribosomes. Comparison of the human gene with a partial sequence from the chimpanzee 28S gene yields divergence rates for the two species: 0.8% for conserved regions of the gene and 3.7% for a variable region. The rapid divergence rates of variable regions in the ribosomal gene may permit answers to the question of time of separation of closely related species.

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