Antioxidative and Anti-inflammatory Effects of Plant-derived Hypoglycemic Medicines: An Systematic Review

Overview

Journal Curr Top Med Chem

Publisher Bentham Science Publishers

Specialty Chemistry

Date 2024 Apr 22

PMID 38644706

Authors

Mohammad Sadegh Adel-Mehraban

Ozra Tabatabaei-Malazy

Azadeh Manayi

Sudabeh Alatab

Shahrzad Mohseni

Saeed Ebrahimi Fana

Pooria Asili

Roodabeh Bahramsoltani

Fataneh Esmaeili

Bayan Azizi

Affiliations

Soon will be listed here.

Abstract

Background: The activation of oxidative stress and inflammatory conditions has been associated with acceleration in diabetes (DM) onset and complications. Despite various anti-DM medications, there is a growing trend to discover inexpensive and effective treatments with low adverse effects from plants as one of the promising sources for drug development.

Objective: This study aimed to systematically investigate the simultaneous anti-inflammatory and antioxidant effects of plant-derived hypoglycemic medicines in diabetic experimental models.

Methods: The search terms consisted of "diabetes", "herbal medicine", "antioxidant", "Inflammatory biomarker", and their equivalents among PubMed, Scopus, Web of Science, and Cochrane Library databases up to 17 August 2021.

Results: Throughout the search of databases, 201 eligible experimental studies were recorded. The results showed that the most commonly assessed inflammatory and oxidative stress biomarkers were tumor necrosis factor (TNF)-α, interleukin (IL) 6, IL-1β, IL-10, malondialdehyde (MDA), and nitric oxide (NO). The activity of antioxidant enzymes, including superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT) were assessed in the present review. Among herbal treatments, , and Lam. were most commonly used for diabetic complications. Due to the dispersion of the treatments, meta-analysis was not applicable.

Conclusion: Our findings showed that the application of different plant-derived hypoglycemic treatments in animal models improved diabetes and its complications, as well as modulated concomitant inflammatory and oxidative stress biomarkers. These findings suggest that plant-based antidiabetic medicines and food supplements have the potential to manage diabetes and its complications.

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