Photocatalytic Enantioselective Radical Cascade Multicomponent Minisci Reaction of β-Carbolines Using Diazo Compounds As Radical Precursors

Overview

Journal Adv Sci (Weinh)

Specialty Biomedical Engineering

Date 2024 Apr 19

PMID 38639395

Authors

Yi-Jie Gu

Mu-Peng Luo

Hua Yuan

Guo-Kai Liu

Shou-Guo Wang

Affiliations

Soon will be listed here.

Abstract

Here, a photocatalytic asymmetric multicomponent cascade Minisci reaction of β-carbolines with enamides and diazo compounds is reported, enabling an effective enantioselective radical C─H functionalization of β-carbolines with high yields and enantioselectivity (up to 83% yield and 95% ee). This enantioselective multicomponent Minisci protocol exhibits step economy, high chemo-/enantio-selective control, and good functional group tolerance, allowing access to a variety of valuable chiral β-carbolines. Notably, diazo compounds are suitable radical precursors in enantioselective cascade radical reactions. Moreover, the efficiency and practicality of this approach are demonstrated by the asymmetric synthesis of bioactive compounds and natural products.

Citing Articles

Photocatalytic Enantioselective Radical Cascade Multicomponent Minisci Reaction of β-Carbolines Using Diazo Compounds as Radical Precursors.

Gu Y, Luo M, Yuan H, Liu G, Wang S Adv Sci (Weinh). 2024; 11(25):e2402272.

PMID: 38639395 PMC: 11220658. DOI: 10.1002/advs.202402272.

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