Phytochemical Analysis and Biological Investigation of (Burm.f.) Swartz

Overview

Journal Front Pharmacol

Date 2024 Apr 19

PMID 38638865

Authors

Umme Habiba Juhi

Heba A S El-Nashar

Abdullah Al Faruq

Md Shimul Bhuia

Irin Sultana

Syedul Alam

Farah Abuyousef

Nail Saleh

Mohamed El-Shazly

Muhammad Torequl Islam

Affiliations

Soon will be listed here.

Abstract

is an evergreen ornamental small fern, belonging to the family Pteridaceae, that grows in warm and rocky regions worldwide. Many species of genus are evidently endowed with important phytochemicals and bioactivities. This study aimed to perform a preliminary phytochemical analysis of leaves alongside an evaluation of free radical scavenging, anti-inflammatory, antimicrobial, and clot lysis activities of extract fractions. A preliminary phytochemical analysis was done after fractionation of ethanolic extract (ECT) with -hexane (HCT) and chloroform (CCT). Then, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, egg albumin and RBC membrane stabilization tests, disc diffusion, and human blood clot lysis assays were performed. Phytochemical investigations suggested that the plant is rich in alkaloids, glycosides, tannins, and flavonoids. All obtained fractions exhibited concentration-dependent radical scavenging, inhibition of egg protein denaturation and RBC membrane lysis capacities. Except for antifungal tests, ECT exhibited better DPPH radical scavenging, anti-inflammatory, antibacterial, and clot lysis capacities than HCT and CCT fractions. However, all fractions exhibited a mild anti-inflammatory activity. might be a good source of antioxidant, anti-microbial, and anti-atherothrombotic agents. Further studies are required to isolate and characterize the active principles liable for each bioactivity, along with possible molecular interactions.

Citing Articles

Qualitative Phytochemical Analysis and Assessments of Analgesic and Antidiarrheal Activity of the Methanolic Leaf Extract of Cheilanthes tenuifolia: In Vivo Study.

Rakib A, Chowdhury R, Bhuia M, Al Hasan M, Sheikh S, Ansari S Immun Inflamm Dis. 2024; 12(11):e70055.

PMID: 39508723 PMC: 11542299. DOI: 10.1002/iid3.70055.

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