Denosumab-induced Autoimmune Hepatitis: Case Report

Overview

Journal Clin Case Rep

Date 2024 Apr 18

PMID 38634089

Authors

Jawaher J Alotaibi

Bushra Albuqami

Wadha Alotaibi

Rawan M Al Ghamdi

Mohammed Alaskar

Hadi Kuriry

Nasser Almasri

Affiliations

Soon will be listed here.

Abstract

This report described a patient not known to have a hepatic disease, found to have a drug-induced autoimmune hepatitis from denosumab. This is an unreported side effect, and here, we presented the possible predisposing factors and suggested monitoring parameters.

Citing Articles

Denosumab-induced autoimmune hepatitis: Case report.

Alotaibi J, Albuqami B, Alotaibi W, Al Ghamdi R, Alaskar M, Kuriry H Clin Case Rep. 2024; 12(4):e8736.

PMID: 38634089 PMC: 11021674. DOI: 10.1002/ccr3.8736.

References

Mack C, Adams D, Assis D, Kerkar N, Manns M, Mayo M . Diagnosis and Management of Autoimmune Hepatitis in Adults and Children: 2019 Practice Guidance and Guidelines From the American Association for the Study of Liver Diseases. Hepatology. 2019; 72(2):671-722. DOI: 10.1002/hep.31065. View

Liu Z, Kaplowitz N . Immune-mediated drug-induced liver disease. Clin Liver Dis. 2002; 6(3):755-74. DOI: 10.1016/s1089-3261(02)00025-9. View

Kim B, Choi H, Ki M, Kim K, Jang E, Jeong S . Population-based prevalence, incidence, and disease burden of autoimmune hepatitis in South Korea. PLoS One. 2017; 12(8):e0182391. PMC: 5542613. DOI: 10.1371/journal.pone.0182391. View

Tan C, Ho D, Wang L, Kumar R . Drug-induced autoimmune hepatitis: A minireview. World J Gastroenterol. 2022; 28(24):2654-2666. PMC: 9260871. DOI: 10.3748/wjg.v28.i24.2654. View

Mieli-Vergani G, Vergani D, Czaja A, Manns M, Krawitt E, Vierling J . Autoimmune hepatitis. Nat Rev Dis Primers. 2018; 4:18017. DOI: 10.1038/nrdp.2018.17. View

Nunes D, Breton M, de Jesus Monteiro C, Dos Santos J . Drug Induced Liver Injury: Perspective of the Adverse Drug Reaction Reports to the Portuguese Pharmacovigilance System from 2010 to 2019. Healthcare (Basel). 2021; 9(12). PMC: 8702164. DOI: 10.3390/healthcare9121630. View

Malnick S, Maor Y, Melzer E, Ziv-Sokolowskaia N, Neuman M . Severe hepatocytotoxicity linked to denosumab. Eur Rev Med Pharmacol Sci. 2017; 21(1 Suppl):78-85. View

Dalekos G, Samakidou A, Lyberopoulou A, Banakou E, Gatselis N . Recent advances in the diagnosis and management of autoimmune hepatitis. Pol Arch Intern Med. 2022; 132(9). DOI: 10.20452/pamw.16334. View

Naranjo C, Busto U, Sellers E, Sandor P, Ruiz I, Roberts E . A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981; 30(2):239-45. DOI: 10.1038/clpt.1981.154. View

10.

Ostrovsky V, Malnick S, Ish-Shalom S, Ziv Sokolowskaia N, Yosepovich A, Neuman M . Denosumab-Induced Immune Hepatitis. Biomedicines. 2021; 9(1). PMC: 7830192. DOI: 10.3390/biomedicines9010076. View

11.

Danan G, Benichou C . Causality assessment of adverse reactions to drugs--I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. J Clin Epidemiol. 1993; 46(11):1323-30. DOI: 10.1016/0895-4356(93)90101-6. View

12.

Oo Y, Hubscher S, Adams D . Autoimmune hepatitis: new paradigms in the pathogenesis, diagnosis, and management. Hepatol Int. 2010; 4(2):475-93. PMC: 2900560. DOI: 10.1007/s12072-010-9183-5. View

13.

Czaja A . Diagnosis and Management of Autoimmune Hepatitis: Current Status and Future Directions. Gut Liver. 2016; 10(2):177-203. PMC: 4780448. DOI: 10.5009/gnl15352. View

14.

Urzua A, Pizarro C, Gajardo A, Poniachik R, Pavez C, Cattaneo M . Autoimmune Hepatitis with Acute Presentation: Clinical, Biochemical, and Histological Features of 126 Patients. Can J Gastroenterol Hepatol. 2022; 2022:6470847. PMC: 9529506. DOI: 10.1155/2022/6470847. View

15.

Alotaibi J, Albuqami B, Alotaibi W, Al Ghamdi R, Alaskar M, Kuriry H . Denosumab-induced autoimmune hepatitis: Case report. Clin Case Rep. 2024; 12(4):e8736. PMC: 11021674. DOI: 10.1002/ccr3.8736. View

16.

Castiella A, Zapata E, Lucena M, Andrade R . Drug-induced autoimmune liver disease: A diagnostic dilemma of an increasingly reported disease. World J Hepatol. 2014; 6(4):160-8. PMC: 4009471. DOI: 10.4254/wjh.v6.i4.160. View

17.

Danan G, Teschke R . RUCAM in Drug and Herb Induced Liver Injury: The Update. Int J Mol Sci. 2015; 17(1). PMC: 4730261. DOI: 10.3390/ijms17010014. View