Osteocalcin Associates with Bone Mineral Density and Gene Polymorphisms in Type 1 and Type 2 Diabetes

Overview

Journal Adv Lab Med

Publisher De Gruyter

Specialty Biochemistry

Date 2024 Apr 18

PMID 38634086

Authors

Carla Ramirez Ruiz

Nerea Varo Cenarruzabeitia

Miriam Martinez Villanueva

Antonio M Hernandez Martinez

Jose Antonio Noguera Velasco

Affiliations

Soon will be listed here.

Abstract

Objectives: Bone metabolism is impaired in diabetes mellitus (DM). Our objective is to evaluate the association of bone turnover markers (BTM) and vitamin D receptor () gene polymorphisms with bone mineral density (BMD) in DM type 1 (T1D) and DM type 2 (T2D).

Methods: A total of 165 patients (53 T1D and 112 T2D) were enrolled. BMD was measured by dual-energy X-ray absorptiometry (DEXA). Plasma osteocalcin (OC), beta-CrossLaps (β-CTX) and N-amino terminal propeptide of type I collagen (P1NP) and gene polymorphisms were evaluated.

Results: Participants were 53 T1D (41 years [31-48]) and 112 T2D (60 years [51-66]). BMD were not statistically different between the groups. OC (p<0.001) and P1NP levels (p<0.001) were higher in patients with T1D. The areas under the curve for the prediction of bone pathology were 0.732 (p=0.038) for OC in T1D and 0.697 (p=0.007) in T2D. A significant association was found between lower lumbar BMD and the A allele of (p=0.03), the A allele of (p=0.04) and the allele C of the (p=0.046). Also, a significant correlation was found with higher OC levels and the G allele of (p=0.044), C allele of (p=0.011), T allele of (p=0.006) and with C allele of (p=0.004).

Conclusions: The high negative predictive value of the cut-off point for OC suggests that could be useful in excluding the risk suffering bone loss, allowing offering a personalized clinical approach to prevent this pathology.

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