Factors Influencing Peak Bone Mass Gain

Overview

Journal Front Med

Specialty General Medicine

Date 2020 Jun 11

PMID 32519297

Citations 61

Authors

Xiaowei Zhu

Houfeng Zheng

Affiliations

Soon will be listed here.

Abstract

Bone mass is a key determinant of osteoporosis and fragility fractures. Epidemiologic studies have shown that a 10% increase in peak bone mass (PBM) at the population level reduces the risk of fracture later in life by 50%. Low PBM is possibly due to the bone loss caused by various conditions or processes that occur during adolescence and young adulthood. Race, gender, and family history (genetics) are responsible for the majority of PBM, but other factors, such as physical activity, calcium and vitamin D intake, weight, smoking and alcohol consumption, socioeconomic status, age at menarche, and other secondary causes (diseases and medications), play important roles in PBM gain during childhood and adolescence. Hence, the optimization of lifestyle factors that affect PBM and bone strength is an important strategy to maximize PBM among adolescents and young people, and thus to reduce the low bone mass or osteoporosis risk in later life. This review aims to summarize the available evidence for the common but important factors that influence bone mass gain during growth and development and discuss the advances of developing high PBM.

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References

Ferrari S, Rizzoli R . Gene variants for osteoporosis and their pleiotropic effects in aging. Mol Aspects Med. 2005; 26(3):145-67. DOI: 10.1016/j.mam.2005.01.002. View

Pisani P, Renna M, Conversano F, Casciaro E, Di Paola M, Quarta E . Major osteoporotic fragility fractures: Risk factor updates and societal impact. World J Orthop. 2016; 7(3):171-81. PMC: 4794536. DOI: 10.5312/wjo.v7.i3.171. View

Si L, Winzenberg T, Jiang Q, Chen M, Palmer A . Projection of osteoporosis-related fractures and costs in China: 2010-2050. Osteoporos Int. 2015; 26(7):1929-37. DOI: 10.1007/s00198-015-3093-2. View

Rizzoli R, Bianchi M, Garabedian M, McKay H, Moreno L . Maximizing bone mineral mass gain during growth for the prevention of fractures in the adolescents and the elderly. Bone. 2009; 46(2):294-305. DOI: 10.1016/j.bone.2009.10.005. View

Hernandez C, Beaupre G, Carter D . A theoretical analysis of the relative influences of peak BMD, age-related bone loss and menopause on the development of osteoporosis. Osteoporos Int. 2003; 14(10):843-7. DOI: 10.1007/s00198-003-1454-8. View

Boreham C, McKay H . Physical activity in childhood and bone health. Br J Sports Med. 2011; 45(11):877-9. DOI: 10.1136/bjsports-2011-090188. View

Forlino A, Marini J . Osteogenesis imperfecta. Lancet. 2015; 387(10028):1657-71. PMC: 7384887. DOI: 10.1016/S0140-6736(15)00728-X. View

Jha S, Chapman M, Roszko K . When Low Bone Mineral Density and Fractures Is Not Osteoporosis. Curr Osteoporos Rep. 2019; 17(5):324-332. PMC: 6819255. DOI: 10.1007/s11914-019-00529-7. View

Gordon C, Bachrach L, Carpenter T, Crabtree N, Fuleihan G, Kutilek S . Dual energy X-ray absorptiometry interpretation and reporting in children and adolescents: the 2007 ISCD Pediatric Official Positions. J Clin Densitom. 2008; 11(1):43-58. DOI: 10.1016/j.jocd.2007.12.005. View

10.

Kyriakou A, Shepherd S, Mason A, Ahmed S . A critical appraisal of vertebral fracture assessment in paediatrics. Bone. 2015; 81:255-259. DOI: 10.1016/j.bone.2015.07.032. View

11.

Adiotomre E, Summers L, Allison A, Walters S, Digby M, Broadley P . Diagnostic accuracy of DXA compared to conventional spine radiographs for the detection of vertebral fractures in children. Eur Radiol. 2016; 27(5):2188-2199. PMC: 5374187. DOI: 10.1007/s00330-016-4556-3. View

12.

Adams J . Quantitative computed tomography. Eur J Radiol. 2009; 71(3):415-24. DOI: 10.1016/j.ejrad.2009.04.074. View

13.

Hunter D, de Lange M, Andrew T, Snieder H, MacGregor A, Spector T . Genetic variation in bone mineral density and calcaneal ultrasound: a study of the influence of menopause using female twins. Osteoporos Int. 2001; 12(5):406-11. DOI: 10.1007/s001980170110. View

14.

Faulkner R, Bailey D . Osteoporosis: a pediatric concern?. Med Sport Sci. 2007; 51:1-12. DOI: 10.1159/000102993. View

15.

Bachrach L, Hastie T, Wang M, Narasimhan B, Marcus R . Bone mineral acquisition in healthy Asian, Hispanic, black, and Caucasian youth: a longitudinal study. J Clin Endocrinol Metab. 1999; 84(12):4702-12. DOI: 10.1210/jcem.84.12.6182. View

16.

Berger C, Goltzman D, Langsetmo L, Joseph L, Jackson S, Kreiger N . Peak bone mass from longitudinal data: implications for the prevalence, pathophysiology, and diagnosis of osteoporosis. J Bone Miner Res. 2010; 25(9):1948-57. PMC: 5101070. DOI: 10.1002/jbmr.95. View

17.

Bonjour J, Chevalley T . Pubertal timing, bone acquisition, and risk of fracture throughout life. Endocr Rev. 2014; 35(5):820-47. DOI: 10.1210/er.2014-1007. View

18.

Recker R, Davies K, Hinders S, Heaney R, Stegman M, Kimmel D . Bone gain in young adult women. JAMA. 1992; 268(17):2403-8. View

19.

Teegarden D, Proulx W, Martin B, Zhao J, McCabe G, Lyle R . Peak bone mass in young women. J Bone Miner Res. 1995; 10(5):711-5. DOI: 10.1002/jbmr.5650100507. View

20.

Bishop N, Arundel P, Clark E, Dimitri P, Farr J, Jones G . Fracture prediction and the definition of osteoporosis in children and adolescents: the ISCD 2013 Pediatric Official Positions. J Clin Densitom. 2014; 17(2):275-80. DOI: 10.1016/j.jocd.2014.01.004. View