TINU: A Multisystemic Inflammatory Disorder-Case Report and Literature Review

Overview

Journal Case Rep Nephrol

Publisher Wiley

Specialty Nephrology

Date 2024 Apr 18

PMID 38633468

Authors

Juan Montejo-Hernandez

Jorge Rico-Fontalvo

Jose Cabrales

Shuchi Anand

Maria Cristina Martinez-Avila

Claudia Duran-Merino

Luis Arias-Restrepo

Camilo Andres Gomez Duran

Affiliations

Soon will be listed here.

Abstract

. The syndrome of tubulointerstitial nephritis and uveitis (TINU) is a rare oculorenal condition, mainly seen in children and women. The underlying cause of this disease is unknown. . We report a 24-year-old male without any past medical history, diagnosed with bilateral uveitis and azotemia. Biopsy revealed tubulointerstitial nephritis, consistent with TINU syndrome. Fluorescein angiogram revealed peripheral retinal vasculitis. . TINU is a rare disorder that needs to be distinguished from sarcoidosis, Sjogren's disease, and tuberculosis. Treatment is indicated in patients with progressive renal insufficiency, consisting of steroid therapy. Most patients recover kidney function. Its early recognition is important to offer the best chance of organ preservation.

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