Modified C-reactive Protein Might Be a Target Autoantigen of TINU Syndrome

Overview

Journal Clin J Am Soc Nephrol

Specialty Nephrology

Date 2010 Sep 4

PMID 20813859

Citations 48

Authors

Ying Tan

Feng Yu

Zhen Qu

Tao Su

Guang-Qun Xing

Li-Hua Wu

Feng-Mei Wang

Gang Liu

Liu Yang

Ming-Hui Zhao

Affiliations

Soon will be listed here.

Abstract

Background And Objectives: The cross-reactive antigen(s) of tubulointerstitial nephritis and uveitis (TINU) syndrome from renal tubulointerstitia and ocular tissue remain unidentified. The authors' recent study demonstrated that the presence of serum IgG autoantibodies against modified C-reactive protein (mCRP) was closely associated with the intensity of tubulointerstitial lesions in lupus nephritis. The study presented here investigates the possible role of IgG autoantibodies against mCRP in patients with TINU syndrome.

Design, Setting, Participants, & Measurements: mCRP autoantibodies were screened by ELISA with purified human C-reactive protein in 9 patients with TINU syndrome, 11 with drug-associated acute interstitial nephritis, 20 with IgA nephropathy, 19 with minimal change disease, 20 with ANCA-associated vasculitis, 6 with Sjogren's syndrome, and 12 with amyloidosis. mCRP expression was analyzed by immunohistochemistry in renal biopsy specimens from the 9 patients with TINU syndrome and 40 from disease controls. Frozen normal human kidney and iris were used to demonstrate co-localization of human IgG and mCRP from patients with TINU syndrome with laser scanning confocal microscopy.

Results: The mCRP autoantibodies were detected in all nine patients with TINU syndrome, significantly higher than that of those with disease controls (P < 0.05). The renal histologic score of mCRP in TINU syndrome was significantly higher than that in disease controls (P < 0.05). The staining of mCRP and human IgG were co-localized in renal and ocular tissues.

Conclusions: It is concluded that mCRP might be a target autoantigen in TINU syndrome.

Citing Articles

A Comprehensive Review of Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome.

Bograd A, Heiligenhaus A, Reuter S, Tappeiner C Biomedicines. 2025; 13(2).

PMID: 40002713 PMC: 11853424. DOI: 10.3390/biomedicines13020300.

Vaccines and the Eye: Current Understanding of the Molecular and Immunological Effects of Vaccination on the Eye.

Zou Y, Kamoi K, Zong Y, Zhang J, Yang M, Ohno-Matsui K Int J Mol Sci. 2024; 25(9).

PMID: 38731972 PMC: 11084287. DOI: 10.3390/ijms25094755.

Tubulointerstitial Nephritis and Uveitis: A Case Report.

Mira M, Khanin Y, Sekulic M, Jordanovski D Cureus. 2024; 16(3):e56405.

PMID: 38633918 PMC: 11023732. DOI: 10.7759/cureus.56405.

TINU: A Multisystemic Inflammatory Disorder-Case Report and Literature Review.

Montejo-Hernandez J, Rico-Fontalvo J, Cabrales J, Anand S, Martinez-Avila M, Duran-Merino C Case Rep Nephrol. 2024; 2024:3909755.

PMID: 38633468 PMC: 11023721. DOI: 10.1155/2024/3909755.

The Role of Anti-mCRP Autoantibodies in Lupus Nephritis.

Yuan M, Tan Y, Zhao M Kidney Dis (Basel). 2023; 9(5):317-325.

PMID: 37901707 PMC: 10601961. DOI: 10.1159/000530928.

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