Mesenchymal Stem Cell Therapy in Ischemic Stroke Trials. A Systematic Review

Overview

Journal Regen Ther

Date 2024 Apr 18

PMID 38633415

Authors

Ester Monivas Gallego

Mercedes Zurita Castillo

Affiliations

Soon will be listed here.

Abstract

Cerebrovascular accidents, also known as strokes, are the leading cause of permanent disability in society, presenting significant socioeconomic and healthcare costs. They can be caused by ischemic factors or hemorrhages, with ischemic strokes being the most common among the population. Therapies for patients suffering from this condition are limited and primarily focus on acute-phase treatment. In recent years, there has been an increase in cellular therapies, employing Stem Cells to mitigate or eliminate the consequences arising from this disease. Mesenchymal Stem Cells (MSCs) hold substantial therapeutic potential in Nervous System pathologies due to their low antigenicity and capacity to differentiate into various human tissues, such as adipogenic, chondrogenic, and osteogenic tissues. This study conducts a literature review using the "clinical trials" and "Pubmed" database, summarizing all ongoing clinical trials for ischemic strokes that utilize MSCs as treatment.

Citing Articles

miRNA in blood-brain barrier repair: role of extracellular vesicles in stroke recovery.

Sprincl V, Romanyuk N Front Cell Neurosci. 2025; 19:1503193.

PMID: 39990970 PMC: 11842324. DOI: 10.3389/fncel.2025.1503193.

Artificial intelligence powers regenerative medicine into predictive realm.

Garmany A, Terzic A Regen Med. 2024; 19(12):611-616.

PMID: 39660914 PMC: 11703382. DOI: 10.1080/17460751.2024.2437281.

Neuroplasticity therapy using glia-like cells derived from human mesenchymal stem cells for the recovery of cerebral infarction sequelae.

Lee E, Lee M, Ryu Y, Nam S, Kim R, Song S Mol Ther. 2024; 33(1):356-374.

PMID: 39563032 PMC: 11764092. DOI: 10.1016/j.ymthe.2024.11.022.

Potential Mechanism and Perspectives of Mesenchymal Stem Cell Therapy for Ischemic Stroke: A Review.

Zhu P, Tan H, Gao H, Wang J, Liu Y, Yang D Glob Med Genet. 2024; 11(4):278-284.

PMID: 39224463 PMC: 11368559. DOI: 10.1055/s-0044-1790231.

References

Wang F, Tang H, Zhu J, Zhang J . Transplanting Mesenchymal Stem Cells for Treatment of Ischemic Stroke. Cell Transplant. 2018; 27(12):1825-1834. PMC: 6300770. DOI: 10.1177/0963689718795424. View

Barnes B, Stansbury N, Brown D, Garson L, Gerard G, Piccoli N . Risk-Based Monitoring in Clinical Trials: Past, Present, and Future. Ther Innov Regul Sci. 2021; 55(4):899-906. PMC: 8082746. DOI: 10.1007/s43441-021-00295-8. View

Chamorro A, Amaro S, Castellanos M, Gomis M, Urra X, Blasco J . Uric acid therapy improves the outcomes of stroke patients treated with intravenous tissue plasminogen activator and mechanical thrombectomy. Int J Stroke. 2017; 12(4):377-382. DOI: 10.1177/1747493016684354. View

Burns T, Verfaillie C, Low W . Stem cells for ischemic brain injury: a critical review. J Comp Neurol. 2009; 515(1):125-44. PMC: 4112591. DOI: 10.1002/cne.22038. View

Dharmasaroja P . Bone marrow-derived mesenchymal stem cells for the treatment of ischemic stroke. J Clin Neurosci. 2008; 16(1):12-20. DOI: 10.1016/j.jocn.2008.05.006. View

Lu D, Chen B, Liang Z, Deng W, Jiang Y, Li S . Comparison of bone marrow mesenchymal stem cells with bone marrow-derived mononuclear cells for treatment of diabetic critical limb ischemia and foot ulcer: a double-blind, randomized, controlled trial. Diabetes Res Clin Pract. 2011; 92(1):26-36. DOI: 10.1016/j.diabres.2010.12.010. View

Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D . Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006; 8(4):315-7. DOI: 10.1080/14653240600855905. View

Caplan L . Posterior circulation ischemia: then, now, and tomorrow. The Thomas Willis Lecture-2000. Stroke. 2000; 31(8):2011-23. DOI: 10.1161/01.str.31.8.2011. View

Lee R, Lee M, Wu C, Silva A, Possoit H, Hsieh T . Cerebral ischemia and neuroregeneration. Neural Regen Res. 2018; 13(3):373-385. PMC: 5900490. DOI: 10.4103/1673-5374.228711. View

10.

Gallego J, Herrera M, Jerico I, Munoz R, Aymerich N, Martinez-Vila E . [Stroke in the XXI century. Emergency care]. An Sist Sanit Navar. 2008; 31 Suppl 1:15-29. View

11.

Liang J, Zhang H, Hua B, Wang H, Lu L, Shi S . Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study. Ann Rheum Dis. 2010; 69(8):1423-9. DOI: 10.1136/ard.2009.123463. View

12.

Powers W, Rabinstein A, Ackerson T, Adeoye O, Bambakidis N, Becker K . Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American.... Stroke. 2019; 50(12):e344-e418. DOI: 10.1161/STR.0000000000000211. View

13.

Chandra A, Stone C, Du X, Li W, Huber M, Bremer R . The cerebral circulation and cerebrovascular disease III: Stroke. Brain Circ. 2018; 3(2):66-77. PMC: 6126259. DOI: 10.4103/bc.bc_12_17. View

14.

Bagheri-Mohammadi S . Protective effects of mesenchymal stem cells on ischemic brain injury: therapeutic perspectives of regenerative medicine. Cell Tissue Bank. 2020; 22(2):249-262. DOI: 10.1007/s10561-020-09885-6. View

15.

Grysiewicz R, Thomas K, Pandey D . Epidemiology of ischemic and hemorrhagic stroke: incidence, prevalence, mortality, and risk factors. Neurol Clin. 2008; 26(4):871-95, vii. DOI: 10.1016/j.ncl.2008.07.003. View

16.

Murphy M, Moncivais K, Caplan A . Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine. Exp Mol Med. 2013; 45:e54. PMC: 3849579. DOI: 10.1038/emm.2013.94. View

17.

Bang O, Lee J, Lee P, Lee G . Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol. 2005; 57(6):874-82. DOI: 10.1002/ana.20501. View

18.

Brown C, McKee C, Bakshi S, Walker K, Hakman E, Halassy S . Mesenchymal stem cells: Cell therapy and regeneration potential. J Tissue Eng Regen Med. 2019; 13(9):1738-1755. DOI: 10.1002/term.2914. View

19.

Kuriakose D, Xiao Z . Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives. Int J Mol Sci. 2020; 21(20). PMC: 7589849. DOI: 10.3390/ijms21207609. View

20.

Herpich F, Rincon F . Management of Acute Ischemic Stroke. Crit Care Med. 2020; 48(11):1654-1663. PMC: 7540624. DOI: 10.1097/CCM.0000000000004597. View