Cerebral Ischemia and Neuroregeneration

Overview

Journal Neural Regen Res

Date 2018 Apr 7

PMID 29623912

Citations 78

Authors

Reggie H C Lee

Michelle H H Lee

Celeste Y C Wu

Alexandre Couto E Silva

Harlee E Possoit

Tsung-Han Hsieh

Alireza Minagar

Hung Wen Lin

Affiliations

Soon will be listed here.

Abstract

Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide. Although stroke (a form of cerebral ischemia)-related costs are expected to reach 240.67 billion dollars by 2030, options for treatment against cerebral ischemia/stroke are limited. All therapies except anti-thrombolytics (i.e., tissue plasminogen activator) and hypothermia have failed to reduce neuronal injury, neurological deficits, and mortality rates following cerebral ischemia, which suggests that development of novel therapies against stroke/cerebral ischemia are urgently needed. Here, we discuss the possible mechanism(s) underlying cerebral ischemia-induced brain injury, as well as current and future novel therapies (i.e., growth factors, nicotinamide adenine dinucleotide, melatonin, resveratrol, protein kinase C isozymes, pifithrin, hypothermia, fatty acids, sympathoplegic drugs, and stem cells) as it relates to cerebral ischemia.

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