Microglia and Macrophage Metabolism: a Regulator of Cerebral Gliomas

Overview

Journal Cell Biosci

Publisher Biomed Central

Specialty Biology

Date 2024 Apr 17

PMID 38632627

Authors

Yue Deng

Qinyan Chen

Chao Wan

Yajie Sun

Fang Huang

Yan Hu

Kunyu Yang

Affiliations

Soon will be listed here.

Abstract

Reciprocal interactions between the tumor microenvironment (TME) and cancer cells play important roles in tumorigenesis and progression of glioma. Glioma-associated macrophages (GAMs), either of peripheral origin or representing brain-intrinsic microglia, are the majority population of infiltrating immune cells in glioma. GAMs, usually classified into M1 and M2 phenotypes, have remarkable plasticity and regulate tumor progression through different metabolic pathways. Recently, research efforts have increasingly focused on GAMs metabolism as potential targets for glioma therapy. This review aims to delineate the metabolic characteristics of GAMs within the TME and provide a summary of current therapeutic strategies targeting GAMs metabolism in glioma. The goal is to provide novel insights and therapeutic pathways for glioma by highlighting the significance of GAMs metabolism.

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