The Role of Autophagy in Odontogenesis, Dental Implant Surgery, Periapical and Periodontal Diseases

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2024 Apr 13

PMID 38613351

Authors

Sevinc Inan

Emre Baris

Affiliations

Soon will be listed here.

Abstract

Autophagy is a cellular process that is evolutionarily conserved, involving the sequestration of damaged organelles and proteins into autophagic vesicles, which subsequently fuse with lysosomes for degradation. Autophagy controls the development of many diseases by influencing apoptosis, inflammation, the immune response and different cellular processes. Autophagy plays a significant role in the aetiology of disorders associated with dentistry. Autophagy controls odontogenesis. Furthermore, it is implicated in the pathophysiology of pulpitis and periapical disorders. It enhances the survival, penetration and colonization of periodontal pathogenic bacteria into the host periodontal tissues and facilitates their escape from host defences. Autophagy plays a crucial role in mitigating exaggerated inflammatory reactions within the host's system during instances of infection and inflammation. Autophagy also plays a role in the relationship between periodontal disease and systemic diseases. Autophagy promotes wound healing and may enhance implant osseointegration. This study reviews autophagy's dento-alveolar effects, focusing on its role in odontogenesis, periapical diseases, periodontal diseases and dental implant surgery, providing valuable insights for dentists on tooth development and dental applications. A thorough examination of autophagy has the potential to discover novel and efficacious treatment targets within the field of dentistry.

Citing Articles

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The role of autophagy in odontogenesis, dental implant surgery, periapical and periodontal diseases.

Inan S, Baris E J Cell Mol Med. 2024; 28(8):e18297.

PMID: 38613351 PMC: 11015398. DOI: 10.1111/jcmm.18297.

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