Metabolic Signaling in Cancer Metastasis

Overview

Journal Cancer Discov

Specialty Oncology

Date 2024 Apr 9

PMID 38592405

Authors

Sarah Krieg

Sara Isabel Fernandes

Constantinos Kolliopoulos

Ming Liu

Sarah-Maria Fendt

Affiliations

Soon will be listed here.

Abstract

Significance: Effective drugs for the prevention and treatment of metastases will have an immediate impact on patient survival. To overcome the current lack of such drugs, a better understanding of the molecular processes that are an Achilles heel in metastasizing cancer cells is needed. One emerging opportunity is the metabolic changes cancer cells need to undergo to successfully metastasize and grow in distant organs. Mechanistically, these metabolic changes not only fulfill energy and biomass demands, which are often in common between cancer and normal but fast proliferating cells, but also metabolic signaling which enables the cell state changes that are particularly important for the metastasizing cancer cells.

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