» Articles » PMID: 38556942

What is the Role of Microbial Biotechnology and Genetic Engineering in Medicine?

Overview
Specialty Microbiology
Date 2024 Apr 1
PMID 38556942
Authors
Affiliations
Soon will be listed here.
Abstract

Microbial products are essential for developing various therapeutic agents, including antibiotics, anticancer drugs, vaccines, and therapeutic enzymes. Genetic engineering techniques, functional genomics, and synthetic biology unlock previously uncharacterized natural products. This review highlights major advances in microbial biotechnology, focusing on gene-based technologies for medical applications.

Citing Articles

Bacillus subtilis surface display technology: applications in bioprocessing and sustainable manufacturing.

Bahrulolum H, Ahmadian G Biotechnol Biofuels Bioprod. 2025; 18(1):34.

PMID: 40089785 DOI: 10.1186/s13068-025-02635-4.


Advancing microbiota therapeutics: the role of synthetic biology in engineering microbial communities for precision medicine.

Nazir A, Hussain F, Raza A Front Bioeng Biotechnol. 2024; 12:1511149.

PMID: 39698189 PMC: 11652149. DOI: 10.3389/fbioe.2024.1511149.


Cationic Surface Charge Engineering of Recombinant Transthyretin Remarkably Increases the Inhibitory Potency Against Amyloid β-Protein Fibrillogenesis.

Lin X, Xu T, Hou W, Dong X, Sun Y Molecules. 2024; 29(21).

PMID: 39519665 PMC: 11547489. DOI: 10.3390/molecules29215023.


Harnessing the Power of the Gut Microbiome: A Review of Supplementation Therapies for Metabolic Syndrome.

Reddy N, Chiwhane A, Acharya S, Kumar S, Parepalli A, Nelakuditi M Cureus. 2024; 16(9):e69682.

PMID: 39429422 PMC: 11489520. DOI: 10.7759/cureus.69682.


Combinatorial biosynthesis of novel aminoglycoside antibiotics via pathway engineering.

Aboshanab K, Alshahrani M, Alafeefy A AMB Express. 2024; 14(1):103.

PMID: 39285100 PMC: 11405602. DOI: 10.1186/s13568-024-01753-w.


References
1.
Zhu D, Mengyue M, Qimuge A, Bilige B, Baiyin T, Temuqile T . Oral Delivery of SARS-CoV-2 DNA Vaccines Using Attenuated as a Carrier in Rat. Mol Gen Microbiol Virol. 2023; 37(3):159-166. PMC: 9790184. DOI: 10.3103/S0891416822030107. View

2.
Moreau Bachelard C, Coquan E, Du Rusquec P, Paoletti X, Le Tourneau C . Risks and benefits of anticancer drugs in advanced cancer patients: A systematic review and meta-analysis. EClinicalMedicine. 2021; 40:101130. PMC: 8548931. DOI: 10.1016/j.eclinm.2021.101130. View

3.
Demain A, Martens E . Production of valuable compounds by molds and yeasts. J Antibiot (Tokyo). 2016; 70(4):347-360. PMC: 7094691. DOI: 10.1038/ja.2016.121. View

4.
Maksimenko O, Malinovskaya J, Shipulo E, Osipova N, Razzhivina V, Arantseva D . Doxorubicin-loaded PLGA nanoparticles for the chemotherapy of glioblastoma: Towards the pharmaceutical development. Int J Pharm. 2019; 572:118733. DOI: 10.1016/j.ijpharm.2019.118733. View

5.
Errington J . Cell wall-deficient, L-form bacteria in the 21st century: a personal perspective. Biochem Soc Trans. 2017; 45(2):287-295. PMC: 5390494. DOI: 10.1042/BST20160435. View