» Articles » PMID: 38554166

Marine Natural Products As Novel Treatments for Parasitic Diseases

Overview
Specialty Pharmacology
Date 2024 Mar 30
PMID 38554166
Authors
Affiliations
Soon will be listed here.
Abstract

Parasitic diseases including malaria, leishmaniasis, and trypanosomiasis have received significant attention due to their severe health implications, especially in developing countries. Marine natural products from a vast and diverse range of marine organisms such as sponges, corals, molluscs, and algae have been found to produce unique bioactive compounds that exhibit promising potent properties, including antiparasitic, anti-Plasmodial, anti-Leishmanial, and anti-Trypanosomal activities, providing hope for the development of effective treatments. Furthermore, various techniques and methodologies have been used to investigate the mechanisms of these antiparasitic compounds. Continued efforts in the discovery and development of marine natural products hold significant promise for the future of novel treatments against parasitic diseases.

Citing Articles

Exploring Marine Natural Compounds: Innovative Therapeutic Candidates Against Chagas Disease Through Virtual Screening and Molecular Dynamics.

Maya-Ramirez C, Saih A, Mendez Tenorio A, Wong Baeza C, Nogueda Torres B, Santiago Hernandez J Life (Basel). 2025; 15(2).

PMID: 40003601 PMC: 11856606. DOI: 10.3390/life15020192.


Chemical Changes Under Heat Stress and Identification of Dendrillolactone, a New Diterpene Derivative with a Rare Rearranged Spongiane Skeleton from the Antarctic Marine Sponge .

Profumo A, Avila C, Cutignano A Mar Drugs. 2025; 23(1).

PMID: 39852512 PMC: 11767012. DOI: 10.3390/md23010010.

References
1.
Ahmad A, Siddiqui P, Fayyaz S, Khan K, Iqbal E, Rasheed M . Bioassay Directed Fractionation of Petroleum Ether Extract of Aerial Parts of Ceriops tagal: Isolation of Lupeol as the Nematicidal Agent against Cyst Nematode Heterodera zeae. Chem Biodivers. 2022; 19(3):e202100759. DOI: 10.1002/cbdv.202100759. View

2.
Almaliti J, Malloy K, Glukhov E, Spadafora C, Gutierrez M, Gerwick W . Dudawalamides A-D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens. J Nat Prod. 2017; 80(6):1827-1836. DOI: 10.1021/acs.jnatprod.7b00034. View

3.
Altreuther G, Radeloff I, LeSueur C, Schimmel A, Krieger K . Field evaluation of the efficacy and safety of emodepside plus praziquantel tablets (Profender tablets for dogs) against naturally acquired nematode and cestode infections in dogs. Parasitol Res. 2009; 105 Suppl 1:S23-9. DOI: 10.1007/s00436-009-1492-z. View

4.
Alvarado S, Roberts B, Wright A, Chakrabarti D . The bis(indolyl)imidazole alkaloid nortopsentin a exhibits antiplasmodial activity. Antimicrob Agents Chemother. 2013; 57(5):2362-4. PMC: 3632953. DOI: 10.1128/AAC.02091-12. View

5.
Aminu R, Umar I, Rahman M, Ibrahim M . Stigmasterol retards the proliferation and pathological features of Trypanosoma congolense infection in rats and inhibits trypanosomal sialidase in vitro and in silico. Biomed Pharmacother. 2017; 89:482-489. DOI: 10.1016/j.biopha.2017.02.068. View