Monoterpenic Fragment Analogues of Aplasmomycin As Potential Antimalarial

Overview

Journal J Med Chem

Publisher American Chemical Society

Specialty Chemistry

Date 1991 Sep 1

PMID 1895301

Citations 2

Authors

N Balu

J V Thomas

S V Bhat

Affiliations

Soon will be listed here.

Abstract

Seven analogues of monoterpenic fragment of aplasmomycin were synthesized as targeted antimalarial agents. The potency of the compound 6 was comparable with the sesquiterpene lactone artemisinin and the antibiotic aplasmomycin in vivo against Plasmodium berghei yoelli.

Citing Articles

Marine Natural Products as Novel Treatments for Parasitic Diseases.

Cheng W, Huang Y, Gao H, Bold B, Zhang T, Yang D Handb Exp Pharmacol. 2024; 287():325-393.

PMID: 38554166 DOI: 10.1007/164_2024_712.

Antiplasmodial marine natural products in the perspective of current chemotherapy and prevention of malaria: a review.

Laurent D, Pietra F Mar Biotechnol (NY). 2006; 8(5):433-47.

PMID: 16565802 DOI: 10.1007/s10126-006-6100-y.

Activity of bilobalide, a sesquiterpene from Ginkgo biloba, on Pneumocystis carinii.

Atzori C, Bruno A, Chichino G, Bombardelli E, Scaglia M, Ghione M Antimicrob Agents Chemother. 1993; 37(7):1492-6.

PMID: 8363381 PMC: 188000. DOI: 10.1128/AAC.37.7.1492.