Role of RNA Binding Proteins of the Behavior and Human Splicing (DBHS) Family in Health and Cancer

Overview

Journal RNA Biol

Specialty Molecular Biology

Date 2024 Mar 29

PMID 38551131

Authors

Toshihiko Takeiwa

Kazuhiro Ikeda

Kuniko Horie

Satoshi Inoue

Affiliations

Soon will be listed here.

Abstract

RNA-binding proteins (RBPs) play crucial roles in the functions and homoeostasis of various tissues by regulating multiple events of RNA processing including RNA splicing, intracellular RNA transport, and mRNA translation. The behavior and human splicing (DBHS) family proteins including PSF/SFPQ, NONO, and PSPC1 are ubiquitously expressed RBPs that contribute to the physiology of several tissues. In mammals, DBHS proteins have been reported to contribute to neurological diseases and play crucial roles in cancers, such as prostate, breast, and liver cancers, by regulating cancer-specific gene expression. Notably, in recent years, multiple small molecules targeting DBHS family proteins have been developed for application as cancer therapeutics. This review provides a recent overview of the functions of DBHS family in physiology and pathophysiology, and discusses the application of DBHS family proteins as promising diagnostic and therapeutic targets for cancers.

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