Hybrid Immunity to SARS-CoV-2 Arises from Serological Recall of IgG Antibodies Distinctly Imprinted by Infection or Vaccination

Highlights: ▪ Infection and vaccination elicit unique IgG antibody profiles at the molecular level▪ Immunological imprinting varies between infection (S2/NTD) and vaccination (RBD)▪ Hybrid immunity maintains the imprint of first infection or first vaccination▪ Hybrid immune IgG plasma mAbs have superior neutralization potency and breadth.