Serum Heme Oxygenase-1 Level Predicts Clinical Outcome After Acute Ischemic Stroke

Overview

Journal CNS Neurosci Ther

Specialties Neurology
Pharmacology

Date 2024 Mar 28

PMID 38544366

Authors

Huan Wang

Ting Cui

Yaqi Chen

Mingxi Chen

Shihong Zhang

Xinyi Leng

Deren Wang

Affiliations

Soon will be listed here.

Abstract

Aims: The relationship between heme oxygenase-1 (HO-1) and human ischemic stroke outcome remains unclear, which was investigated in this study.

Methods: Acute ischemic stroke patients admitted within 24 h were enrolled. Serum HO-1 levels at baseline were measured via ELISA. Poor 3-month functional outcome was defined as modified Rankin Scale (mRS) score 3-6. Multivariable-adjusted binary logistic regression and restricted cubic spline models were employed to examine association between serum HO-1 and functional outcome. HO-1's additive prognostic utility was assessed by net reclassification index (NRI) and integrated discrimination improvement (IDI).

Results: Of 194 eligible patients, 79 (40.7%) developed poor functional outcomes at 3-month follow-up. The highest quartile of serum HO-1 was independently associated with a lower risk of poor functional outcome (adjusted OR 0.13, 95% CI 0.04-0.45; p = 0.001) compared with the lowest HO-1 category. The relationship between higher HO-1 levels and reduced risk of poor functional outcome was linear and dose responsive (p = 0.002 for linearity). Incorporating HO-1 into the analysis with conventional factors significantly improved reclassification for poor functional outcomes (NRI = 41.2%, p = 0.004; IDI = 5.0%, p = 0.004).

Conclusions: Elevated serum HO-1 levels at baseline were independently associated with improved 3-month functional outcomes post-ischemic stroke. Serum HO-1 measurement may enhance outcome prediction beyond conventional clinical factors.

Citing Articles

Association between serum levels of insulin-like growth factor-binding proteins at admission and outcomes at 3 months after acute ischemic stroke.

Zhu Y, Wang H, Cui T, Chen M, Chen Y, Wu S Ann Med. 2025; 57(1):2472867.

PMID: 40048365 PMC: 11892070. DOI: 10.1080/07853890.2025.2472867.

Serum heme oxygenase-1 level predicts clinical outcome after acute ischemic stroke.

Wang H, Cui T, Chen Y, Chen M, Zhang S, Leng X CNS Neurosci Ther. 2024; 30(3):e14701.

PMID: 38544366 PMC: 10973699. DOI: 10.1111/cns.14701.

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