State of the Art on the Role of Extracellular Vesicles in the Pathogenesis of Atopic Dermatitis

Overview

Journal Microorganisms

Specialty Microbiology

Date 2024 Mar 28

PMID 38543582

Authors

Marina Passos Torrealba

Fabio Seiti Yamada Yoshikawa

Valeria Aoki

Maria Notomi Sato

Raquel Leao Orfali

Affiliations

Soon will be listed here.

Abstract

Atopic dermatitis (AD) is a chronic and relapsing inflammatory cutaneous disease. The role of host defense and microbial virulence factors in skin colonization, infection, and inflammation perpetuation in AD remains an area of current research focus. Extracellular vesicles (EV) mediate cell-to-cell communication by transporting and delivering bioactive molecules, such as nucleic acids, proteins, and enzymes, to recipient cells. spontaneously secretes extracellular vesicles (SA-derived EVs) which spread throughout the skin layers. Previous research has shown that SA-derived EVs from AD patients can trigger cytokine secretion in keratinocytes, shape the recruitment of neutrophils and monocytes, and induce inflammatory AD-type lesions in mouse models, in addition to their role as exogenous worsening factors for the disease. In this review article, we aim to examine the role of SA-derived EVs in AD physiopathology and its progression, highlighting the recent research in the field and exploring the potential crosstalk between the host and the microbiota.

Citing Articles

Staphylococcus aureus membrane vesicles: an evolving story.

Wang X, Lee J Trends Microbiol. 2024; 32(11):1096-1105.

PMID: 38677977 PMC: 11511790. DOI: 10.1016/j.tim.2024.04.003.

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