Clindamycin Derivatives: Unveiling New Prospects As Potential Antitumor Agents

Overview

Journal Pharmaceuticals (Basel)

Publisher MDPI

Specialty Chemistry

Date 2024 Mar 28

PMID 38543062

Authors

Yiduo Jia

Yinmeng Zhang

Hong Zhu

Affiliations

Soon will be listed here.

Abstract

This study delves into the exploration of Clindamycin derivatives, specifically compounds and , to unveil their antitumor potential by employing a multidisciplinary approach. Screening a repertoire of 200 Clindamycin-associated targets pinpointed the Family A G-protein-coupled receptor as a prominent antitumor candidate. Subsequent analyses unearthed 16 pertinent antitumor proteins, with compound exhibiting robust affinity towards a specific protein via stable hydrogen bonding. Molecular dynamics simulations underscored the adrenergic receptor β as a pivotal target, primarily situated in the plasma membrane and endoplasmic reticulum. These revelations hint towards compound 's potential to bolster natural defense mechanisms against tumors by modulating immune responses within the tumor microenvironment, thus paving the way for novel avenues in antitumor drug development. Furthermore, employing the MTT assay, we evaluated the anti-HepG2 cell activity of compounds and , with 5-fluorouracil serving as the control drug. Results revealed that compound exhibited significant differences ( < 0.01) across all concentrations (2.5, 5, 10 μg/mL) compared to the control group, paralleled by the pronounced differences ( < 0.01) observed with 5-fluorouracil.

Citing Articles

Unraveling the Anti-Cancer Mechanisms of Antibiotics: Current Insights, Controversies, and Future Perspectives.

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PMID: 39858295 PMC: 11762948. DOI: 10.3390/antibiotics14010009.

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