Extracellular Vesicles As Next-Generation Biomarkers in Lung Cancer Patients: A Case Report on Adenocarcinoma and Squamous Cell Carcinoma

Overview

Journal Life (Basel)

Specialty Biology

Date 2024 Mar 28

PMID 38541732

Authors

Monika Ruzycka-Ayoush

Monika Prochorec-Sobieszek

Andrzej Cieszanowski

Maciej Glogowski

Anna Szumera-Cieckiewicz

Joanna Podgorska

Alicja Targonska

Kamil Sobczak

Grazyna Mosieniak

Ireneusz P Grudzinski

Affiliations

Soon will be listed here.

Abstract

Extracellular vesicles (EVs) released from primary cell lines, originating from resected tissues during biopsies in patients with non-small cell lung cancer (NSCLC) revealing adenocarcinoma and squamous cell carcinoma subtypes, were examined for membrane proteomic fingerprints using a proximity barcoding assay. All the collected EVs expressed canonical tetraspanins (CD9, CD63, and CD81) highly coexpressed with molecules such as lysosome-associated membrane protein-1 (LAMP1-CD107a), sialomucin core protein 24 (CD164), Raph blood group (CD151), and integrins (ITGB1 and ITGA2). This representation of the protein molecules on the EV surface may provide valuable information on NSCLC subtypes and offer new diagnostic opportunities as next-generation biomarkers in personalized oncology.

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